3-叔-丁基环己-2-烯-1-酮合成路线 （共 17 条）
反应条件
1: 57 percent / phosphorus tribromide / benzene; triethylamine / 36 h / Ambient temperature
2: 1.) cuprous cyanide / 1.) THF, -50 deg C, 10 min, 2.) THF, 0 deg C, 2.5 h.
View Scheme
参考文献
Arain, Munawar F.; Haynes, Richard K.; Vonwiller, Simone C.; Hambley, Trevor W.
Australian Journal of Chemistry, 1988 , vol. 41, # 4 p. 505 - 526
反应条件
2: 63 percent / formic acid / 0.08 h / Heating
View Scheme
参考文献
Liotta, Dennis; Zima, George; Saindane, Manohar
Journal of Organic Chemistry, 1982 , vol. 47, # 7 p. 1258 - 1267
反应条件
tert.-butyl lithium
1) ether, pentane, -23 deg C, 2 h; 2) ether, pentane, -78 deg C, 50 min; Multistep reaction. Yields of byproduct given;
参考文献
Coates, Robert M.; Jin, Alan Qingwu
Journal of Organic Chemistry, 1997 , vol. 62, # 21 p. 7475 - 7478
反应条件
1: 1.) NaBH4, 2.) AcOH / 1.) EtOH, room temp., 2.) EtOH, room temp., 6 h
2: 2.) TsOH / 1.) THF, 2.) dioxane, H2O, room temp., 3 h
View Scheme
参考文献
Comasseto, Joao V.; Lo, Wai L.; Petragnani, Nicola
Tetrahedron, 1997 , vol. 53, # 22 p. 7445 - 7460
反应条件
toluene-4-sulfonic acid
1.) THF, 2.) dioxane, H2O, room temp., 3 h; Yield given. Multistep reaction;
参考文献
Comasseto, Joao V.; Lo, Wai L.; Petragnani, Nicola
Tetrahedron, 1997 , vol. 53, # 22 p. 7445 - 7460
反应条件
(i) CuI, pentane, Et2O, (ii) /BRN= 2418493/; Multistep reaction;
参考文献
Sum,F.-W.; Weiler,L.
Canadian Journal of Chemistry, 1979 , vol. 57, p. 1431 - 1441
反应条件
sodium tetrahydroborate; cerium(III) chloride heptahydrate in methanol
T=0 - 20°C; Luche reduction; Inert atmosphere;
参考文献
Coote, Susannah C.; O'Brien, Peter; Whitwood, Adrian C.
Organic and Biomolecular Chemistry, 2008 , vol. 6, # 23 p. 4299 - 4314
