(4S)-4-甲基-己酸合成路线 （共 36 条）
反应条件
1: 99 percent / oxalyl chloride, DMF / CH2Cl2 / 2 h / Ambient temperature 2: 1.) n-BuLi / 1.) THF, -78 deg C, 20 min, 2.) THF, -78 deg C, 2.5 h; -78 deg C to room temperature View Scheme
参考文献
Stoermer, Doris; Caron, Stephane; Heathcock, Clayton H.
Journal of Organic Chemistry, 1996 , vol. 61, # 26 p. 9115 - 9125
反应条件
1: H2SO4 View Scheme
参考文献
Thakar,K.A.; Pathak,U.S.
Journal of the Indian Chemical Society, 1965 , vol. 42, p. 109 - 111
反应条件
1: methanol; sodium / Electrolysis 2: lithium alanate View Scheme
参考文献
Milburn; Truter
Journal of the Chemical Society, 1954 , p. 3344,3347
反应条件
lithium aluminium tetrahydride; diethyl ether Heating;
参考文献
Kelly, Stephen M.; Buchecker, Richard
Helvetica Chimica Acta, 1988 , vol. 71, p. 451 - 460
反应条件
sodium chloride in water; dimethyl sulfoxide
T=150 - 175°C; 4 h; Heating / reflux;
参考文献
Lead Chemical Co., Ltd.
Patent: US6348484 B1, 2002 ;
Location in patent: Page column 10-11; 32 ;
反应条件
potassium permanganate
参考文献
Akasaka, Kazuaki; Meguro, Hiroshi; Ohrui, Hiroshi
Tetrahedron Letters, 1997 , vol. 38, # 39 p. 6853 - 6856
反应条件
hydrogen; nickel
T=100°C; P=76000 Torr;
参考文献
Lardicci,L. et al.
Journal of Organic Chemistry, 1966 , vol. 31, p. 1534 - 1538
反应条件
dichloromethane; ozone
anschliessend mit wss.Wasserstoffperoxid und Natriumhydrogencarbonat;
参考文献
Djerassi; Geller
Journal of the American Chemical Society, 1959 , vol. 81, p. 2789,2794
反应条件
sodium carbonate; sodium thiosulfate; silver(l) oxide in 1,4-dioxane; water
T=90 - 100°C;
参考文献
Desai; Pathak
Journal of the Indian Chemical Society, 1984 , vol. 61, # 9 p. 814 - 816
反应条件
trifluoroacetic acid in dichloromethane
1.) 0 deg C, 2.5 h, 2.) room temperature, 2.5 h;
参考文献
Stoermer, Doris; Caron, Stephane; Heathcock, Clayton H.
Journal of Organic Chemistry, 1996 , vol. 61, # 26 p. 9115 - 9125
