(4S)-4-甲基-己酸合成路线 （共 36 条）
反应条件
1: 57 percent / Br2; PPh3; imidazole / CH2Cl2
2: NaOEt / ethanol / Heating
3: KOH / methanol / Heating
4: 4 h / 190 °C
View Scheme
参考文献
Larsson, Michael; Nguyen, Ba-Vu; Hoegberg, Hans-Erik; Hedenstroem, Erik
European Journal of Organic Chemistry, 2001 , # 2 p. 353 - 363
反应条件
(i) aq. KOH, (ii) H2SO4; Multistep reaction;
参考文献
Thakar,K.A.; Pathak,U.S.
Journal of the Indian Chemical Society, 1965 , vol. 42, p. 109 - 111
反应条件
1: NaOEt / ethanol / Heating
2: KOH / methanol / Heating
3: 4 h / 190 °C
View Scheme
参考文献
Larsson, Michael; Nguyen, Ba-Vu; Hoegberg, Hans-Erik; Hedenstroem, Erik
European Journal of Organic Chemistry, 2001 , # 2 p. 353 - 363
反应条件
1: Br2 / CHCl3
2: KOH / 250 °C
3: (i) MeMgI, (ii) /BRN= 1900390/
4: H2 / Raney-Ni / 100 °C / 76000 Torr
View Scheme
参考文献
Lardicci,L. et al.
Journal of Organic Chemistry, 1966 , vol. 31, p. 1534 - 1538
反应条件
(i) Mg, (ii) /BRN= 1900390/, Et2O; Multistep reaction;
参考文献
Salvadori,P. et al.
Gazzetta Chimica Italiana, 1968 , vol. 98, p. 1400 - 1416
反应条件
1: 91 percent / CsF / dimethylformamide
2: NaOH / aq. methanol / Saponification
3: NaCl / dimethylsulfoxide / 130 °C
View Scheme
参考文献
Lorca, Miguel; Kurosu, Michio
Tetrahedron Letters, 2001 , vol. 42, # 13 p. 2431 - 2434
反应条件
1: 1.) LDA, 2.) N,N'-dimethylpropyleneurea / 1.) THF, -78 deg C, 50 min, 2.) -78 deg C, 5 min; -42 deg C, 3 h; -42 deg C to room temperature
2: 66 percent / TFA / CH2Cl2 / 1.) 0 deg C, 2.5 h, 2.) room temperature, 2.5 h
View Scheme
参考文献
Stoermer, Doris; Caron, Stephane; Heathcock, Clayton H.
Journal of Organic Chemistry, 1996 , vol. 61, # 26 p. 9115 - 9125
反应条件
1: (i) MeMgI, (ii) /BRN= 1900390/
2: H2 / Raney-Ni / 100 °C / 76000 Torr
View Scheme
参考文献
Lardicci,L. et al.
Journal of Organic Chemistry, 1966 , vol. 31, p. 1534 - 1538
反应条件
1: NaOH / aq. methanol / Saponification
2: NaCl / dimethylsulfoxide / 130 °C
View Scheme
参考文献
Lorca, Miguel; Kurosu, Michio
Tetrahedron Letters, 2001 , vol. 42, # 13 p. 2431 - 2434
反应条件
hydrogenchloride
T=120°C; 48 h;
参考文献
Isogai, Akira; Suzuki, Akinori; Tamura, Saburo; Higashikawa, Shizuo; Kuyama, Shimpei
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 7 p. 1405 - 1411
