(S)-(+)-2-甲基丁酸合成路线 （共 111 条）
参考文献
Kjaer; Hansen
Acta Chemica Scandinavica (1947-1973), 1957 , vol. 11, p. 898
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Freudenberg; Lwowski
Justus Liebigs Annalen der Chemie, 1955 , vol. 594, p. 76,85
参考文献
Casanova,J. et al.
Journal of Organic Chemistry, 1966 , vol. 31, p. 3473 - 3482
反应条件
1: diethyl ether 2: diethyl ether 3: oxalic acid View Scheme
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 24, p. 110,113
反应条件
4-(N,N-dimethlyamino)pyridine in dichloromethane T=20°C; 0.166667 h; Inert atmosphere;
参考文献
Schoenleber, Marc; Hilgraf, Robert; Pfaltz, Andreas
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 13 p. 2033 - 2038
参考文献
Kenyon; Symons
Journal of the Chemical Society, 1953 , p. 3580,3583
反应条件
1: 87 percent / LiAlH4, MeOH / tetrahydrofuran / 4 h / Heating 2: 49 percent / Br2, triphenylphosphite / CH2Cl2 / 3 h / Ambient temperature View Scheme
参考文献
Bestmann, Hans Juergen; Frighetto, Rosa T. S.; Frighetto, Nelson; Vostrowsky, Otto
Liebigs Annalen der Chemie, 1988 , p. 877 - 880
反应条件
1: 65 percent / P2O5 / benzene / 4 h / Heating 2: 40 percent / zinc amalgam, 37 percent aq. HCl / methanol / 3 h / Heating 3: 1) ozonized oxygen, 2) 10percent aq. NaOH, 36percent H2O2 / 1) pentane, 0 deg C, 10 h, 2) ethanol, reflux, 24 h View Scheme
参考文献
Menicagli, R.; Botteghi, C.; Marchetti, M.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 57 - 59
反应条件
1: (i) SOCl2, (ii) AlCl3, /BRN= 969212/ 2: (i) H2, Pd-C, (ii) Na, EtOH, liq. NH3 View Scheme
参考文献
Smolinsky,G.; Feuer,B.I.
Journal of the American Chemical Society, 1964 , vol. 86, p. 3085 - 3088
反应条件
1: 97 percent / DCC / CH2Cl2 / 3 h / 4 °C 2: 1 mg / 4-(dimethylamino)pyridine / pyridine / 16 h / 25 °C 3: 2.8 g / pyridine / 8 h / 0 °C 4: 1.8 g / DBU / pyridine / 3 h / Heating 5: 1.44 g / acetic acid; tetrahydrofuran; H2O / 8 h / 25 °C 6: 65 percent / pyridinium chlorochromate / CH2Cl2 / 4 h / 25 °C 7: 1.) NaH, 2.) n-BuLi / 1.) THF, 0 deg C, 10 min, 2.) THF-hexane, 0 deg C, 10 min, 3.) 0 deg C, 15 min 8: 34 mg / Zn(BH4)2 / diethyl ether / 1 h / 25 °C 9: 32 mg / p-toluenesulfonic acid monohydrate / benzene / 0.25 h / 25 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 105, # 3 p. 593 - 601
反应条件
das Kalium-Salz.Electrolysis;
参考文献
Brenner; Mislow
Journal of Organic Chemistry, 1956 , vol. 21, p. 1312
