(S)-(+)-2-甲基丁酸合成路线 （共 111 条）
反应条件
thionyl chloride T=80°C; 2 h; Reflux;
参考文献
Gibbons, Simon; Malkinson, John P.; Shiu, Winnie
Patent: US2010/222426 A1, 2010 ;
Location in patent: Page/Page column 6-7 ;
反应条件
in benzene T=20°C; Condensation;
参考文献
Shivanyuk, Alexander; Rissanen, Kari; Koerner, Steffi K.; Rudkevich, Dmitry M.; Rebek Jr., Julius
Helvetica Chimica Acta, 2000 , vol. 83, # 8 p. 1778 - 1790
反应条件
(i) SOCl2, (ii) aq. NH4OH, (iii) P2O5; Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 35, # 10 p. 3410 - 3416
反应条件
dicyclohexyl-carbodiimide in dichloromethane T=4°C; 3 h;
参考文献
Journal of the American Chemical Society, , vol. 105, # 3 p. 593 - 601
反应条件
1: 87 percent / LiAlH4, MeOH / tetrahydrofuran / 4 h / Heating 2: 49 percent / Br2, triphenylphosphite / CH2Cl2 / 3 h / Ambient temperature 3: 1.) Mg; 2.) CuBr / 1.) THF, 2h, reflux; 2.) THF, 2h, reflux 4: 91 percent / H2O, p-TosOH / methanol View Scheme
参考文献
Bestmann, Hans Juergen; Frighetto, Rosa T. S.; Frighetto, Nelson; Vostrowsky, Otto
Liebigs Annalen der Chemie, 1988 , p. 877 - 880
反应条件
1: LiAlH4 / diethyl ether / 16 h / 40 °C 2: Et3N / CH2Cl2 / 1 h / -10 °C View Scheme
参考文献
Capon, Robert J.; Skene, Colin; Liu, Edward Hsiang-Te; Lacey, Ernest; Gill, Jennifer H.; Heiland, Kirstin; Friedel, Thomas
Journal of Natural Products, 2004 , vol. 67, # 8 p. 1277 - 1282
反应条件
methanol; lithium aluminium tetrahydride in tetrahydrofuran 4 h; Heating;
参考文献
Bestmann, Hans Juergen; Frighetto, Rosa T. S.; Frighetto, Nelson; Vostrowsky, Otto
Liebigs Annalen der Chemie, 1988 , p. 877 - 880
反应条件
1: sulfuric acid
2: water; hydrazine
View Scheme
参考文献
Kjaer; Hansen
Acta Chemica Scandinavica (1947-1973), 1957 , vol. 11, p. 898
反应条件
LovD; recombinant LovF from Aspergillus terreus; S-adenosyl-L-methionine chloride; NADPH; Malonyl coenzyme A
pH=7.4; aq. phosphate buffer; Kinetics;
参考文献
Xie, Xinkai; Meehan, Michael J.; Xu, Wei; Dorrestein, Pieter C.; Tang, Yi
Journal of the American Chemical Society, 2009 , vol. 131, p. 8388 - 8389
反应条件
2,4-diamino-pyrimidine; dicyclohexyl-carbodiimide in dichloromethane
48 h; Heating;
参考文献
Pelletier, William S.; Dailey, Oliver D.; Mody, Naresh V.
Journal of Organic Chemistry, 1981 , vol. 46, # 16 p. 3284 - 3293
