(S)-(+)-2-甲基丁酸合成路线 （共 111 条）
反应条件
1: 95 percent / dimethylcarbamyl chloride / CH2Cl2 / 120 h / Ambient temperature 2: 2.) 5N aq. HCl / 1.) Et2O, 1 night, 2.) Et2O, 12 h 3: 96 percent / NaBH4, NaOH / methanol / 12 h 4: 92 percent / 85percent H2SO4 / 2 h / 110 - 120 °C 5: 1.) O3, 2.) 35percent aq. H2O2, 5percent aq. NaOH / 1.) CH2Cl2, RT, 24 h, 2.) EtOH, reflux, 24 h View Scheme
参考文献
Synthetic Communications, , vol. 22, # 18 p. 2645 - 2651
反应条件
1: 2.) 5N aq. HCl / 1.) Et2O, 1 night, 2.) Et2O, 12 h 2: 96 percent / NaBH4, NaOH / methanol / 12 h 3: 92 percent / 85percent H2SO4 / 2 h / 110 - 120 °C 4: 1.) O3, 2.) 35percent aq. H2O2, 5percent aq. NaOH / 1.) CH2Cl2, RT, 24 h, 2.) EtOH, reflux, 24 h View Scheme
参考文献
Synthetic Communications, , vol. 22, # 18 p. 2645 - 2651
反应条件
1: 96 percent / NaBH4, NaOH / methanol / 12 h 2: 92 percent / 85percent H2SO4 / 2 h / 110 - 120 °C 3: 1.) O3, 2.) 35percent aq. H2O2, 5percent aq. NaOH / 1.) CH2Cl2, RT, 24 h, 2.) EtOH, reflux, 24 h View Scheme
参考文献
Synthetic Communications, , vol. 22, # 18 p. 2645 - 2651
反应条件
1: 3-chloroperbenzoic acid / CH2Cl2 2: 95 percent / dimethylcarbamyl chloride / CH2Cl2 / 120 h / Ambient temperature 3: 2.) 5N aq. HCl / 1.) Et2O, 1 night, 2.) Et2O, 12 h 4: 96 percent / NaBH4, NaOH / methanol / 12 h 5: 92 percent / 85percent H2SO4 / 2 h / 110 - 120 °C 6: 1.) O3, 2.) 35percent aq. H2O2, 5percent aq. NaOH / 1.) CH2Cl2, RT, 24 h, 2.) EtOH, reflux, 24 h View Scheme
参考文献
Synthetic Communications, , vol. 22, # 18 p. 2645 - 2651
反应条件
1: HCl / methanol 2: NaIO4, KMnO4, K2CO3 / H2O; acetone View Scheme
参考文献
Chemistry Letters, , p. 1415 - 1418
反应条件
1: sinocrassoside B5 With water; potassium hydroxide in 1,4-dioxane T=37°C; 1 h; 2: (4-nitropjenyl)methyl N,N'-bis(1-methylethyl)carbamimidate in 1,4-dioxane; dichloromethane T=80°C; 1 h;
参考文献
Morikawa, Toshio; Xie, Haihui; Wang, Tao; Matsuda, Hisashi; Yoshikawa, Masayuki
Chemical and Pharmaceutical Bulletin, 2008 , vol. 56, # 10 p. 1438 - 1444
反应条件
hydrogenchloride T=100°C; 16 h; Yield given;
参考文献
Agricultural and Biological Chemistry, , vol. 44, # 6 p. 1351 - 1356
反应条件
1: stoloniferin XI With potassium hydroxide in water Hydrolysis; 3 h; Heating; 2: diazomethane in diethyl ether Methylation;
参考文献
Phytochemistry, , vol. 48, # 5 p. 837 - 841
反应条件
1: stoloniferin VIII With potassium hydroxide in water Hydrolysis; 3 h; Heating; 2: diazomethane in diethyl ether Methylation;
参考文献
Phytochemistry, , vol. 48, # 5 p. 837 - 841
反应条件
1: stoloniferin IX With potassium hydroxide in water Hydrolysis; 3 h; Heating; 2: diazomethane in diethyl ether Methylation;
参考文献
Phytochemistry, , vol. 48, # 5 p. 837 - 841
