3',5'-二-O-乙酰基-2'-脱氧腺苷合成路线 （共 16 条）
反应条件
1: 82 percent / pyridine, TMCl / 48 h / 100 °C 2: 98 percent / pyridine / H2O / 4 h View Scheme
参考文献
Samano, Vicente; Miles, Robert W.; Robins, Morris J.
Journal of the American Chemical Society, 1994 , vol. 116, # 20 p. 9331 - 9332
反应条件
1: NH3; methanol; ethanol 2: 2,6-dimethyl-pyridine; DMF 3: ueber mehrere Stufen View Scheme
参考文献
Hayes et al.
Journal of the Chemical Society, 1955 , p. 808,810
反应条件
CAL in phosphate buffer; acetone
T=20°C; Deacetylation;
参考文献
Ciuffreda, Pierangela; Casati, Silvana; Santaniello, Enzo
Tetrahedron, 2000 , vol. 56, # 20 p. 3239 - 3243
反应条件
n-butyllithium; 2,2,2-trifluoroethanol in hexane
T=20°C; 3.5 h;
参考文献
Nowak, Ireneusz; Jones, Carl T.; Robins, Morris J.
Journal of Organic Chemistry, 2006 , vol. 71, # 8 p. 3077 - 3081
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran; water
T=20°C; 24 h; Mechanism; regioselective reaction;
参考文献
Babu Kumar, Arun; Manetsch, Roman
European Journal of Organic Chemistry, 2014 , vol. 2014, # 17 p. 3551 - 3555
反应条件
1: 64 percent / n-pentyl nitrite / tetrahydrofuran / 72 h / 50 °C
2: 71 percent / NH3 / ethanol / 48 h / Ambient temperature
View Scheme
参考文献
Nair; Chamberlain
Synthesis, 1984 , vol. NO. 5, p. 401 - 403
