1,2,3,6,7,8-六氢芘合成路线 （共 41 条）
反应条件
bromine in acetic acid T=20°C; 1.5 h;
参考文献
OXFORD GENE TECHNOLOGY IP LIMITED
Patent: EP1506959 A2, 2005 ;
Location in patent: Page 64 ;
参考文献
Vollmann et al.
Justus Liebigs Annalen der Chemie, 1937 , vol. 531, p. 1,143
反应条件
1: bromine / acetic acid 2: dehydrogenation View Scheme
参考文献
Konieczny,M.; Harvey,R.G.
Journal of Organic Chemistry, 1979 , vol. 44, # 13 p. 2158 - 2160
反应条件
1: acetic acid anhydride; HNO3 2: tetrachloro-<1,4>benzoquinone; xylene 3: ethanol; N2H4*H2O; palladium/charcoal View Scheme
参考文献
Bavin
Canadian Journal of Chemistry, 1959 , vol. 37, p. 1614
反应条件
1: 74 percent / trifluoroacetic anhydride, SnCl4 / CH2Cl2 / 0.5 h / 0 °C
2: 69 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) / benzene / 2.5 h / Heating
3: 20percent aq. KOH, Zn, CuSO4*5H2O, pyridine / 4 h / 90 °C
4: 45percent aq. KOH / methanol / 1.5 h / Heating
View Scheme
参考文献
Konieczny,M.; Harvey,R.G.
Journal of Organic Chemistry, 1979 , vol. 44, # 13 p. 2158 - 2160
反应条件
1: Br2
2: DDQ
3: (i) nBuLi, (ii) /BRN= 969135/
4: (i) NBS, (PhCO)2O2, (ii) /BRN= 4652394/
5: aq. KOH
6: HF
View Scheme
参考文献
Konieczny,M.; Harvey,R.G.
Journal of Organic Chemistry, 1979 , vol. 44, # 13 p. 2158 - 2160
反应条件
AlCl3, aluminium chloride in dichloromethane
T=0 - 20°C; Inert atmosphere;
参考文献
Laali, Kenneth K.; Arrica, Maria A.; Okazaki, Takao; Bunge, Scott D.
European Journal of Organic Chemistry, 2008 , # 36 p. 6093 - 6105
反应条件
AlCl3, aluminium chloride in dichloromethane
T=0 - 20°C; Friedel Crafts acylation; 4.5 h;
参考文献
Filichev, Vyacheslav V.; Astakhova, Irina V.; Malakhov, Andrei D.; Korshun, Vladimir A.; Pedersen, Erik B.
Chemistry - A European Journal, 2008 , vol. 14, # 32 p. 9968 - 9980
参考文献
Vollmann et al.
Justus Liebigs Annalen der Chemie, 1937 , vol. 531, p. 1,143
反应条件
copper(II) nitrate in acetic anhydride
6 h; Ambient temperature;
参考文献
Braken-van Leersum, A. M. van den; Tintel, C.; Zelfde, M. van't; Cornelisse, J.; Lugtenburg, J.
Recueil des Travaux Chimiques des Pays-Bas, 1987 , vol. 106, # 4 p. 120 - 128
