4-(1,1-二甲基乙基)-2-嘧啶胺合成路线 （共 6 条）
反应条件
1: 1-methylguanidine hydrochloride With ethanol; sodium T=20°C; 0.5 h; 2: 1-dimethylamino-4,4-dimethyl-1-penten-3-one in ethanol 20 h; Heating / reflux;
参考文献
Sunesis Pharmaceuticals, Inc.
Patent: US2009/36419 A1, 2009 ;
Location in patent: Page/Page column 83 ;
US 20090036419 A1
参考文献
Breuker, J.; Plas, H. C. van der
Recueil: Journal of the Royal Netherlands Chemical Society, 1983 , vol. 102, # 7-8 p. 367 - 372
反应条件
1: 81 percent / NaOEt / ethanol / 2 h / Heating 2: 67 percent / KOH / methanol / 5 h / Heating 3: 83 percent / 7 h / Heating View Scheme
参考文献
Schenone, Pietro; Sansebastiano, Laura; Mosti, Luisa
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 2 p. 295 - 305
反应条件
1: 67 percent / KOH / methanol / 5 h / Heating 2: 83 percent / 7 h / Heating View Scheme
参考文献
Schenone, Pietro; Sansebastiano, Laura; Mosti, Luisa
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 2 p. 295 - 305
参考文献
Schenone, Pietro; Sansebastiano, Laura; Mosti, Luisa
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 2 p. 295 - 305
参考文献
Clark et al.
Journal of the American Chemical Society, 1946 , vol. 68, p. 99
