2-氨基-5-溴-6-氯吡嗪合成路线 （共 4 条）
反应条件
N-bromosuccinmide in dichloromethane T=0°C;
参考文献
CANCER RESEARCH TECHNOLOGY LIMITED; COLLINS, Ian; LAINCHBURY, Michael; MATTHEWS, Thomas Peter; READER, John Charles
Patent: WO2013/68755 A1, 2013 ;
Location in patent: Page/Page column 67, 68 ;
反应条件
N-bromosuccinmide in chloroform T=0 - 20°C;
参考文献
PFIZER INC.
Patent: WO2009/16460 A2, 2009 ;
Location in patent: Page/Page column 79 ;
WO 2009/016460 A2
反应条件
copper(l) iodide; 18-crown-6 ether; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=20 - 200°C; 3.5 h; Inert atmosphere;
参考文献
CANCER RESEARCH TECHNOLOGY LIMITED; COLLINS, Ian; LAINCHBURY, Michael; MATTHEWS, Thomas Peter; READER, John Charles
Patent: WO2013/68755 A1, 2013 ;
Location in patent: Page/Page column 67, 68 ;
