4,4,4-三氟-3-(三氟甲基)-丁酸乙酯合成路线 (共 10 条)
反应条件
1: H2 / Pd-C / ethanol 2: H2SO4 View Scheme
参考文献
Journal of medicinal chemistry, , vol. 11, # 1 p. 138 - 140
反应条件
hydrogen; palladium on activated charcoal
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 9 p. 1282 - 1297
反应条件
triethylamine in water; acetone
参考文献
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), , vol. 24, p. 2410 - 2415
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, , vol. 24, p. 2525 - 2529
反应条件
2: Et3N / acetone; H2O View Scheme
参考文献
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), , vol. 24, p. 2410 - 2415
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, , vol. 24, p. 2525 - 2529
反应条件
1: H2O 2: H2SO4 View Scheme
参考文献
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), , vol. 24, p. 2410 - 2415
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, , vol. 24, p. 2525 - 2529
反应条件
1: P2O5 3: Et3N / acetone; H2O View Scheme
参考文献
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), , vol. 24, p. 2410 - 2415
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, , vol. 24, p. 2525 - 2529
参考文献
Journal of medicinal chemistry, , vol. 11, # 1 p. 138 - 140
参考文献
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), , vol. 24, p. 2410 - 2415
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, , vol. 24, p. 2525 - 2529
反应条件
1: With sodium hydroxide; ethanol; water T=20°C; 18 h; Heating / reflux; 2: With hydrogenchloride in ethanol; water pH=1;
参考文献
Conte-Mayweg, Aurelia; Kuehne, Holger; Luebbers, Thomas; Maugeais, Cyrille; Mueller, Werner; Pflieger, Philippe
Patent: US2006/30613 A1, 2006 ;
Location in patent: Page/Page column 30 ;
反应条件
1: lithium aluminum hydride / diethyl ether / 0.5 h / Heating
2: triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 18 h / Ambient temperature
3: hydrazine monohydrate / ethanol / 1 h / Heating
View Scheme
参考文献
Jacobs, Robert T.; Bernstein, Peter R.; Cronk, Laura A.; Vacek, Edward P.; Newcomb, Lisa F.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 9 p. 1282 - 1297