potassium hydroxide T=120°C; 2 h;

1: 83 percent / NaH / 1,2-dimethoxy-ethane / 1 h / 60 °C 2: 100 percent / H2 / 10percent Pd/C / ethyl acetate / 2 h / 2550.2 Torr / Ambient temperature 3: 89 percent / pyridine / CH2Cl2 / 1 h / Ambient temperature 4: 86 percent / NaOH / ethanol; H2O / 2 h / Heating 5: oxalyl chloride, DMF / CH2Cl2 / 1 h / 0 deg C, 30 min, r.t. 30 min 6: 84 percent / AlCl3 / CH2Cl2 / 0.5 h / Ambient temperature View Scheme