5-O-(4,4-二甲氧基三苯甲游基)-2-脱氧腺苷酸合成路线 （共 11 条）
反应条件
hexafluoroisopropyl alcohol 2 h; Ambient temperature;
参考文献
Tetrahedron Letters, , vol. 36, # 43 p. 7833 - 7836
反应条件
1: pyridine, triethylamine, 4-dimethylaminopyridine / 0.5 h 2: pyridine, triethylamine, 4-dimethylaminopyridine / 2 h / Ambient temperature 3: 29percent aq. ammonia, 4-dimethylaminopyridine / pyridine; triethylamine / 0.5 h / Ambient temperature View Scheme
参考文献
Journal of the American Chemical Society, , vol. 104, # 5 p. 1316 - 1319
反应条件
1: 98 percent / t-butylmagnesium chloride / tetrahydrofuran / 1 h / Ambient temperature 2: CHCl2COOH / CH2Cl2 / 0.17 h / 25 °C 3: Pd(P(C6H5)3)4, P(C6H5)3, HCOOH, n-C4H9NH2 / tetrahydrofuran / 3.7 h / 50 °C View Scheme
参考文献
Hayakawa, Y.; Wakabayashi, S.; Nobori, T.; Noyori, R.
Tetrahedron Letters, 1987 , vol. 28, # 20 p. 2259 - 2262
反应条件
1H-imidazole; methanesulfonic acid; N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide
T=20°C; Etherification; 2 h;
参考文献
Kataoka, Masanori; Hayakawa, Yoshihiro
Journal of Organic Chemistry, 1999 , vol. 64, # 16 p. 6087 - 6089
反应条件
methyl(diphenyl)-phosphine in 1,4-dioxane; water
T=20°C; 0.333333 h;
参考文献
Wada, Takeshi; Ohkubo, Akihiro; Mochizuki, Akira; Sekine, Mitsuo
Tetrahedron Letters, 2001 , vol. 42, # 6 p. 1069 - 1072
反应条件
methylamine in methanol
T=20°C; 16 h;
参考文献
Kurata, Christine; Bradley, Kym; Gaus, Hans; Luu, Nhuy; Cedillo, Isaiah; Ravikumar, Vasulinga T.; Sooy, Kent Van; McArdle, James V.; Capaldi, Daniel C.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 3 p. 607 - 614
反应条件
1: pyridine / 3 h / 20 °C
2: 80 percent / pyridine / 2.5 h / 20 °C
3: 90 percent / MePPh2 / dioxane; H2O / 0.33 h / 20 °C
View Scheme
参考文献
Wada, Takeshi; Ohkubo, Akihiro; Mochizuki, Akira; Sekine, Mitsuo
Tetrahedron Letters, 2001 , vol. 42, # 6 p. 1069 - 1072
反应条件
1: pyridine / 0.33 h / 20 °C
2: pyridine / 3 h / 20 °C
3: 80 percent / pyridine / 2.5 h / 20 °C
4: 90 percent / MePPh2 / dioxane; H2O / 0.33 h / 20 °C
View Scheme
参考文献
Wada, Takeshi; Ohkubo, Akihiro; Mochizuki, Akira; Sekine, Mitsuo
Tetrahedron Letters, 2001 , vol. 42, # 6 p. 1069 - 1072
反应条件
1: 80 percent / pyridine / 2.5 h / 20 °C
2: 90 percent / MePPh2 / dioxane; H2O / 0.33 h / 20 °C
View Scheme
参考文献
Wada, Takeshi; Ohkubo, Akihiro; Mochizuki, Akira; Sekine, Mitsuo
Tetrahedron Letters, 2001 , vol. 42, # 6 p. 1069 - 1072
反应条件
1: 46 percent / 4-(dimethylamino)pyridine (DMAP), pyridine, 4 Angstroem MS / CH2Cl2 / 2.5 h
2: 1M DBU / acetonitrile / 0.03 h
View Scheme
参考文献
Beier, Markus; Pfleiderer, Wolfgang
Helvetica Chimica Acta, 1999 , vol. 82, # 4 p. 633 - 644
