阿利吉仑合成路线

阿利吉仑合成路线（共 110 条）

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反应条件

1: NEt3 / CH2Cl2 2: 85 percent / NaN3; 15-crown-6; DMPU 3: 59 percent / 2-OH-pyridine; NEt3 4: H2; aq. HCl / Pd/C / methanol View Scheme

参考文献

Tetrahedron Letters, , vol. 41, # 51 p. 10085 - 10089

325740-68-9

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173334-57-1阿利吉仑

反应条件

1: 85 percent / NaN3; 15-crown-6; DMPU 2: 59 percent / 2-OH-pyridine; NEt3 3: H2; aq. HCl / Pd/C / methanol View Scheme

参考文献

Tetrahedron Letters, , vol. 41, # 51 p. 10085 - 10089

1309922-72-2

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173334-57-1阿利吉仑

反应条件

1.1: triethylamine; hydrogen / palladium 10 on activated carbon / methanol / 16 h / 3102.97 Torr 2.1: triethylamine; 2-hydroxy-pyridine / 18 h / 80 °C 3.1: triphenylphosphine; diethylazodicarboxylate; 4-nitro-benzoic acid / tetrahydrofuran / 10 h / 0 - 20 °C 3.2: 4 h View Scheme

参考文献

WO2011/64790 A1, ;

1257529-92-2

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173334-57-1阿利吉仑

反应条件

1: 4-(N,N-dimethlyamino)pyridine; triethylamine / toluene / 1 h / 20 °C 2: 88 °C 3: hydrogen / palladium 10 on activated carbon / methanol / 47 h / 50 °C / 3750.38 Torr View Scheme

参考文献

WO2012/34065 A1, ;

1290075-63-6

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173334-57-1阿利吉仑

反应条件

1.1: iodine; magnesium; .alpha.-butylene bromide / tetrahydrofuran / 1 h / Inert atmosphere; Reflux 1.2: 2 h / -78 °C 1.3: -78 °C 2.1: hydrogenchloride; hydrogen; acetic acid / platinum(IV) oxide / water / 3 h / 20 °C / 760.05 Torr 3.1: sodium hydroxide; water / ethanol / 3 h / 50 °C 3.2: 20 °C 3.3: pH 1 - 2 4.1: triethylamine; 2-hydroxy-pyridine / tert-butyl methyl ether / 18 h / 80 °C 5.1: hydrogen; acetic acid / palladium 10 on activated carbon / ethanol / 20 °C / 760.05 Torr 5.2: pH 10 View Scheme

参考文献

US2011/92706 A1, ;

1290075-65-8

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173334-57-1阿利吉仑

反应条件

1.1: hydrogenchloride; hydrogen; acetic acid / platinum(IV) oxide / water / 3 h / 20 °C / 760.05 Torr 2.1: sodium hydroxide; water / ethanol / 3 h / 50 °C 2.2: 20 °C 2.3: pH 1 - 2 3.1: triethylamine; 2-hydroxy-pyridine / tert-butyl methyl ether / 18 h / 80 °C 4.1: hydrogen; acetic acid / palladium 10 on activated carbon / ethanol / 20 °C / 760.05 Torr 4.2: pH 10 View Scheme

参考文献

US2011/92706 A1, ;

1297610-75-3

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173334-57-1阿利吉仑

反应条件

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -40 °C / Inert atmosphere 1.2: 3 h / -40 - -10 °C / Inert atmosphere 2.1: iodine; magnesium; .alpha.-butylene bromide / tetrahydrofuran / 1 h / Reflux; Inert atmosphere 2.2: 6 h / -78 - -35 °C / Inert atmosphere 2.3: -35 °C / Inert atmosphere 3.1: hydrogenchloride; hydrogen; acetic acid / palladium 10 on activated carbon / water / 3 h / 20 °C / 760.05 Torr 4.1: sodium hydrogencarbonate / water; tetrahydrofuran 4.2: 20 °C 5.1: triethylamine; 2-hydroxy-pyridine / tert-butyl methyl ether / 18 h / 80 °C 6.1: hydrogen; acetic acid / palladium 10 on activated carbon / ethanol / 20 °C / 760.05 Torr 6.2: pH 10 View Scheme

参考文献

US2011/105767 A1, ;

1297610-73-1

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173334-57-1阿利吉仑

反应条件

1.1: iodine; magnesium; .alpha.-butylene bromide / tetrahydrofuran / 1 h / Reflux; Inert atmosphere 1.2: 6 h / -78 - -35 °C / Inert atmosphere 1.3: -35 °C / Inert atmosphere 2.1: hydrogenchloride; hydrogen; acetic acid / palladium 10 on activated carbon / water / 3 h / 20 °C / 760.05 Torr 3.1: sodium hydrogencarbonate / water; tetrahydrofuran 3.2: 20 °C 4.1: triethylamine; 2-hydroxy-pyridine / tert-butyl methyl ether / 18 h / 80 °C 5.1: hydrogen; acetic acid / palladium 10 on activated carbon / ethanol / 20 °C / 760.05 Torr 5.2: pH 10 View Scheme

参考文献

US2011/105767 A1, ;

1027526-91-5

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173334-57-1阿利吉仑

反应条件

1.1: hydrogenchloride; hydrogen; acetic acid / palladium 10 on activated carbon / water / 3 h / 20 °C / 760.05 Torr 2.1: sodium hydrogencarbonate / water; tetrahydrofuran 2.2: 20 °C 3.1: triethylamine; 2-hydroxy-pyridine / tert-butyl methyl ether / 18 h / 80 °C 4.1: hydrogen; acetic acid / palladium 10 on activated carbon / ethanol / 20 °C / 760.05 Torr 4.2: pH 10 View Scheme

参考文献

US2011/105767 A1, ;

1297610-74-2

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173334-57-1阿利吉仑

反应条件

1.1: sodium hydrogencarbonate / water; tetrahydrofuran 1.2: 20 °C 2.1: triethylamine; 2-hydroxy-pyridine / tert-butyl methyl ether / 18 h / 80 °C 3.1: hydrogen; acetic acid / palladium 10 on activated carbon / ethanol / 20 °C / 760.05 Torr 3.2: pH 10 View Scheme

参考文献

US2011/105767 A1, ;

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