1-甲基-2-羟甲基-1H-咪唑合成路线 （共 15 条）
反应条件
thionyl chloride T=0 - 70°C; 20 h;
参考文献
SANOFI-AVENTIS
Patent: US2007/185136 A1, 2007 ;
Location in patent: Page/Page column 67 ;
US 20070185136 A1
反应条件
formaldehyd; thionyl chloride in tetrachloromethane; chloroform
参考文献
Schering Corporation
Patent: US4435412 A1, 1984 ;
反应条件
N-bromosuccinmide in tetrahydrofuran
参考文献
Alanine, Alexander; Buettelmann, Bernd; Heitz Neidhart, Marie-Paule; Jaeschke, Georg; Pinard, Emmanuel; Wyler, Rene
Patent: US2002/151715 A1, 2002 ;
反应条件
1: 86 percent / thionyl chloride / CH2Cl2 / 5 h / Ambient temperature
2: 87 percent / dimethylformamide / 4 h / 45 °C
View Scheme
参考文献
Jocelyn
Journal of the Chemical Society, 1957 , p. 3305
反应条件
1: 84 percent / SOCl2 / 0.25 h / Heating
2: 62 percent / dimethylsulfoxide / 2 h / Ambient temperature
3: 84 percent / NaN3, NH4Cl / dimethylformamide / 17 h / 120 - 130 °C
View Scheme
参考文献
Reese, Colin B.; Pei-Zhuo, Zhang
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 19 p. 2291 - 2302
