2-氨基-5-(4-甲氧基苯基)-1H-吡咯-3-羧酸乙酯合成路线 （共 8 条）
反应条件
1: ethyl 2-amidinoacetate hydrochloride With sodium ethanolate in ethanol T=0 - 20°C; Inert atmosphere; 2: 2-bromo-4'-methoxy-acetophenone in ethanol T=20 - 60°C; Inert atmosphere;
参考文献
Sorum, Christopher; Simic, Nebojsa; Sundby, Eirik; Hoff, Bard Helge
Magnetic Resonance in Chemistry, 2010 , vol. 48, # 3 p. 244 - 248
参考文献
Novartis AG
Patent: US6140332 A1, 2000 ;
US 6140332 A
反应条件
1: NH4Cl; K2CO3 / ethanol / 24 h / 22 °C 2: K2CO3 / ethanol / Heating View Scheme
参考文献
Pittala, Valeria; Romeo, Giuseppe; Salerno, Loredana; Siracusa, Maria Angela; Modica, Maria; Materia, Luisa; Mereghetti, Ilario; Cagnotto, Alfredo; Mennini, Tiziana; Marucci, Gabriella; Angeli, Piero; Russo, Filippo
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 1 p. 150 - 153
反应条件
potassium carbonate in ethanol Heating;
参考文献
Pittala, Valeria; Romeo, Giuseppe; Salerno, Loredana; Siracusa, Maria Angela; Modica, Maria; Materia, Luisa; Mereghetti, Ilario; Cagnotto, Alfredo; Mennini, Tiziana; Marucci, Gabriella; Angeli, Piero; Russo, Filippo
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 1 p. 150 - 153
反应条件
1.1: potassium carbonate / water / 0 °C 1.2: Reflux 2.1: sodium ethanolate / ethanol / 0.33 h / 0 °C / Inert atmosphere 2.2: 1.5 h / 60 °C View Scheme
参考文献
Kaspersen, Svein Jacob; Sorum, Christopher; Willassen, Veronica; Fuglseth, Erik; Kjobli, Eli; Bjorkoy, Geir; Sundby, Eirik; Hoff, Brd Helge
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 12 p. 6002 - 6014
反应条件
1.1: hydrogenchloride / 0 - 5 °C 2.1: potassium carbonate / water / 0 °C 2.2: Reflux 3.1: sodium ethanolate / ethanol / 0.33 h / 0 °C / Inert atmosphere 3.2: 1.5 h / 60 °C View Scheme
参考文献
Kaspersen, Svein Jacob; Sorum, Christopher; Willassen, Veronica; Fuglseth, Erik; Kjobli, Eli; Bjorkoy, Geir; Sundby, Eirik; Hoff, Brd Helge
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 12 p. 6002 - 6014
反应条件
sodium ethanolate in ethanol
参考文献
Kaspersen, Svein Jacob; Hoff, Bard Helge; Sundby, Eirik; Charnock, Colin
Bioorganic Chemistry, 2012 , vol. 44, p. 35 - 41,7
反应条件
1.1: formic acid / N,N-dimethyl-formamide / 20 h / 150 °C 2.1: trichlorophosphate / 3 h / 90 °C 2.2: pH 12 View Scheme
参考文献
Kaspersen, Svein Jacob; Hoff, Bard Helge; Sundby, Eirik; Charnock, Colin
Bioorganic Chemistry, 2012 , vol. 44, p. 35 - 41,7
