2-氰基-4'-氟乙酰苯胺合成路线 （共 4 条）
反应条件
1: anhydrous cyanoacetic acid With phosphorus pentachloride in dichloromethane 0.5 h; Reflux; 2: 4-fluoroaniline in dichloromethane 2 h; Reflux;
参考文献
Hazeldine, Stuart; Pachaiyappan, Boobalan; Steinbergs, Nora; Nowotarski, Shannon; Hanson, Allison S.; Casero, Robert A.; Woster, Patrick M.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 17 p. 7378 - 7391
参考文献
Medicinal Chemistry Research, , vol. 22, # 9 p. 4146 - 4157
反应条件
piperidine 0.116667 h; microwave irradiation;
参考文献
Mijin, Dusan; Marinkovic, Aleksandar
Synthetic Communications, 2006 , vol. 36, # 2 p. 193 - 198
反应条件
1: 1,8-diazabicyclo[5.4.0]undec-7-ene / diethylene glycol
2: sulfuric acid / water / 16 h / 100 °C
View Scheme
参考文献
Kallman, Neil J.; Liu, Chin; Yates, Matthew H.; Linder, Ryan J.; Ruble, J. Craig; Kogut, Eugene F.; Patterson, Lawrence E.; Laird, Dana L. T.; Hansen, Marvin M.
Organic Process Research and Development, 2014 , vol. 18, # 4 p. 501 - 510
