2-(2-硝基-4-三氟甲基苯基)乙酸合成路线 （共 19 条）
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 3 h;
参考文献
Boehringer Ingelheim Pharma GmbH and Co. KG
Patent: US6794395 B1, 2004 ;
Location in patent: Page/Page column 18 ;
反应条件
nitric acid in acetic acid
参考文献
US6057323 A1, ;
US 6057323 A
反应条件
sulfuric acid; nitric acid in acetic acid
反应条件
1: With hydrogenchloride; water Heating / reflux; 2:
参考文献
WO2007/106564 A2, ;
Page/Page column 49-50 ;
反应条件
sulfuric acid in acetic acid
参考文献
Israel Journal of Chemistry, , vol. 4, p. 155 - 159
反应条件
1: HNO3, H2SO4 2: K2CO3 / dimethylformamide 3: H2SO4 / aq. acetic acid View Scheme
参考文献
Israel Journal of Chemistry, , vol. 4, p. 155 - 159
反应条件
1: K2CO3 / dimethylformamide 2: H2SO4 / aq. acetic acid View Scheme
参考文献
Israel Journal of Chemistry, , vol. 4, p. 155 - 159
反应条件
sulfuric acid T=65°C; 1.5 h;
参考文献
MERCK PATENT GMBH
Patent: WO2005/75425 A2, 2005 ;
Location in patent: Page/Page column 230 ;
WO 2005/075425 A2
反应条件
potassium carbonate in acetic anhydride
参考文献
Nodiff,E.A. et al.
Journal of Medicinal Chemistry, 1971 , vol. 14, p. 921 - 925
反应条件
1: K2CO3 / acetic anhydride 2: (i) FeSO4, aq. NaOH, (ii) isopentyl nitrite, HCl, EtOH, (iii) Cu, NaH2PO2, aq. H2SO4 View Scheme
参考文献
Nodiff,E.A. et al.
Journal of Medicinal Chemistry, 1971 , vol. 14, p. 921 - 925
