2-(2-硝基-4-三氟甲基苯基)乙酸合成路线 （共 19 条）
反应条件
1: K2CO3 / acetic anhydride 2: (i) FeSO4, aq. NH3, (ii) isopentyl nitrite, HCl, EtOH, (iii) Cu, NaH2PO2, aq. H2SO4 View Scheme
参考文献
Nodiff,E.A. et al.
Journal of Medicinal Chemistry, 1971 , vol. 14, p. 921 - 925
反应条件
potassium carbonate in acetic anhydride
参考文献
Nodiff,E.A. et al.
Journal of Medicinal Chemistry, 1971 , vol. 14, p. 921 - 925
反应条件
1: H2SO4 2: H2 / Pd-C / ethanol View Scheme
参考文献
Kalir,A.; Pelah,Z.
Israel Journal of Chemistry, 1966 , vol. 4, p. 155 - 159
反应条件
hydrogen; palladium 10 on activated carbon in acetic acid 4 h;
参考文献
LIGAND PHARMACEUTICALS INC.
Patent: WO2007/106564 A2, 2007 ;
Location in patent: Page/Page column 49-50 ;
反应条件
oxalyl dichloride; N,N-dimethyl acetamide in dichloromethane
1 h;
参考文献
GLAXO GROUP LIMTED
Patent: WO2007/14054 A2, 2007 ;
Location in patent: Page/Page column 35-36 ;
WO 2007/014054 A2
反应条件
1: K2CO3 / acetic anhydride
2: (i) FeSO4, NaOH, (ii) (diazotization), (iii) Cu
View Scheme
参考文献
Nodiff,E.A. et al.
Journal of Medicinal Chemistry, 1972 , vol. 15, p. 775 - 780
反应条件
potassium carbonate in acetic anhydride
参考文献
Nodiff,E.A. et al.
Journal of Medicinal Chemistry, 1972 , vol. 15, p. 775 - 780
反应条件
1: K2CO3 / acetic anhydride
2: (i) FeSO4, NaOH, (ii) (diazotization), (iii) Cu
View Scheme
参考文献
Nodiff,E.A. et al.
Journal of Medicinal Chemistry, 1972 , vol. 15, p. 775 - 780
反应条件
potassium carbonate in acetic anhydride
参考文献
Nodiff,E.A. et al.
Journal of Medicinal Chemistry, 1972 , vol. 15, p. 775 - 780
