1: (2R,5S)-5-(4-amino-2-oxo-pyrimidin-1-yl)-[1,3]oxathiolan-2-carboxylic acid, 2S-isopropyl-5R-methyl-1R-cyclohexyl ester With sodium tetrahydroborate; dipotassium hydrogenphosphate in methanol; water T=18 - 22°C; 6 h; 2: salicylic acid in water T=78 - 82°C;

1: in water T=10 - 82°C; 8 h; 2: in water

triethylamine in water; ethyl acetate T=25 - 50°C; 5 h; Product distribution / selectivity;