17356-08-0合成路线 （共 1741 条）
参考文献
Jaen, Juan C.; Wise, Lawrence D.; Caprathe, Bradley W.; Tecle, Haile; Bergmeier, Stephen; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 311 - 317
反应条件
1: 5-methyl-cyclohexane-1,3-dione With bromine; sodium acetate; acetic acid
T=15 - 20°C;
2: thiourea T=100°C; 1 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; VAN DER VEEN, Lars; MC CONNELL, Darryl; SCHNEIDER, Siegfried; GRAUERT, Matthias; SCHOOP, Andreas; WUNBERG, Tobias
Patent: WO2010/122091 A1, 2010 ;
Location in patent: Page/Page column 15 ;
WO 2010/122091 A1
反应条件
sodium acetate in acetic acid
T=100°C; 3 h;
参考文献
GILEAD SCIENCES, INC.; MITCHELL, Michael L.; ROETHLE, Paul A.; XU, Lianhong; YANG, Hong; MCFADDEN, Ryan; BABAOGLU, Kerim
Patent: WO2012/145728 A1, 2012 ;
Location in patent: Page/Page column 125 ;
反应条件
potassium hydroxide in ethanol
refluxing in ethanol for 1 h, followed refluxing with aq.KOH for 20 min; acidifying the aqueous phase;
参考文献
Gmelin Handbook: F: PerFHalOrg.SVol.2, 6.2.1.5.2, page 41 - 61
反应条件
iodine
T=20 - 100°C;
参考文献
Hargrave, Karl D.; Hess, Friedrich K.; Oliver, James T.
Journal of Medicinal Chemistry, 1983 , vol. 26, # 8 p. 1158 - 1163
反应条件
potassium carbonate in tetrahydrofuran
T=20°C; 5 h;
参考文献
Ishiwata, Yoshihide; Togo, Hideo
Synlett, 2008 , # 17 p. 2637 - 2641
反应条件
potassium carbonate in tetrahydrofuran
T=20°C; 5 h;
参考文献
Ishiwata, Yoshihide; Togo, Hideo
Synlett, 2008 , # 17 p. 2637 - 2641
参考文献
Garg, C. P.; Sharma, Vinay Prabha; Kapoor, R. P.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1985 , vol. 24, p. 1197 - 1200
反应条件
PEG-400 in water
0.0333333 h; microwave irradiation;
参考文献
Li, Zheng; Wang, Zhi-Yuan; Zhao, Yan-Long; Xing, Yu-Lin; Zhu, Wei
Phosphorus, Sulfur and Silicon and the Related Elements, 2005 , vol. 180, # 12 p. 2745 - 2750
反应条件
in solid
byproducts: CO(NH2)2; glass stoppered pyrex tube; keeping mixture at 120°C for 1h; colour changes from yellow to brown; leaching (dilute (NH4)2S); filtration;
参考文献
Mukherjee, T. K.; Pathak, D. N.
Journal of the Indian Chemical Society, 1987 , vol. 64, p. 306 - 306
