17356-08-0合成路线 （共 1741 条）
反应条件
in ethanol
0.5 h; Heating; Yield given;
参考文献
Okhubo, Mitsuru; Kuno, Atsushi; Nakanishi,Isao; Takasugi, Hisashi
Chemical & Pharmaceutical Bulletin, 1995 , vol. 43, # 9 p. 1497 - 1504
参考文献
Choudhari; Goswami; Thakar
Journal of the Indian Chemical Society, 1978 , vol. 55, # 4 p. 401 - 404
反应条件
in acetone
3 h; Heating;
参考文献
Leydet, Alain; Jeantet-Segonds, Christine; Barthelemy, Philippe; Boyer, Bernard; Roque, Jean Pierre
Recueil des Travaux Chimiques des Pays-Bas-Journal of the Royal Netherlands, 1996 , vol. 115, # 10 p. 421 - 426
反应条件
1: Substitution; 84 h; Heating;
2: With sodium hydroxide in water
Hydrolysis; 1.5 h; Heating; Further stages.;
参考文献
Jaeger, David A.; Su, Dan; Zafar, Abdullah; Piknova, Barbora; Hall, Stephen B.
Journal of the American Chemical Society, 2000 , vol. 122, # 12 p. 2749 - 2757
反应条件
ethanol
Einleiten von Chlor in eine wss.Loesung des Reaktionsprodukts;
参考文献
Miller et al.
Journal of the American Chemical Society, 1940 , vol. 62, p. 2099,2101
反应条件
1: dichloroacetic acid methyl ester; benzaldehyde With sodium methylate in methanol; diethyl ether
T=0°C; 1 h;
2: thiourea in methanol
18 h; Heating / reflux;
参考文献
Ladouceur, Gaetan H.; Schoen, William R.; Burke, Michael J.
Patent: US2003/195352 A1, 2003 ;
Location in patent: Page/Page column 30; 34 ;
反应条件
1: methyl phenylpyruvate With pyridinium tribromide in dichloromethane; acetic acid
T=0°C; 1.5 h;
2: thiourea in ethanol
1 h; Heating / reflux;
参考文献
FUJISAWA PHARMACEUTICAL CO., LTD.,
Patent: WO2004/67521 A1, 2004 ;
Location in patent: Page 108-109 ;
反应条件
1: benzaldehyde; dichloroacetic acid ethyl ester With sodium methylate in diethyl ether
2: methanol; thiourea Heating;
参考文献
Cui, Yong-Mei; Huang, Qing-Qing; Xu, Jie; Chen, Ling-Ling; Li, Jing-Ya; Ye, Qi-Zhuang; Li, Jia; Nan, Fa-Jun
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 16 p. 3732 - 3736
反应条件
in ethanol
RefluxInert atmosphere;
参考文献
Qui, Xiao-Long; Li, Guideng; Wu, Guikai; Zhu, Jiewen; Zhou, Longen; Chen, Phang-Lang; Chamberlin, A. Richard; Lee, Wen-Hwa
Journal of Medicinal Chemistry, 2009 , vol. 52, # 6 p. 1757 - 1767
参考文献
Dickey et al.
Journal of Organic Chemistry, 1955 , vol. 20, p. 499,505
