17356-08-0合成路线 （共 1741 条）
反应条件
hydrogen bromide in water
T=90°C; 5 h;
参考文献
MALLINCKRODT INC.?
Patent: WO2005/42479 A1, 2005 ;
Location in patent: Page/Page column 9-10 ;
反应条件
sodium ethanolate in ethanol
T=80°C; 5 h;
参考文献
Yebga, A.; Menager, S.; Verite, P.; Farnoux, C. Combet; Lafont, O.
European Journal of Medicinal Chemistry, 1995 , vol. 30, # 10 p. 769 - 778
反应条件
potassium carbonate in tetrahydrofuran
T=20°C; 5 h;
参考文献
Ishiwata, Yoshihide; Togo, Hideo
Synlett, 2008 , # 17 p. 2637 - 2641
反应条件
bromine; urea
1) a) methanol, 40 deg C, 30 min, b) water, 20 deg C, 2 h, 2) acetonitrile, 5-8 min, ca. 20 deg C; Yield given. Multistep reaction;
参考文献
Zav'yalov, S. I.; Sitkareva, I. V.; Ezhova, G. I.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1989 , vol. 38, # 1.2 p. 127 - 130
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1989 , vol. 38, # 1 p. 140 - 143
反应条件
in ethanol
Heating; Yield given;
参考文献
Liu; He; Li; Zhong
Current Medicinal Chemistry, 2012 , vol. 19, # 35 p. 6072 - 6079
反应条件
1: ethyl 3-(4-cyanophenyl)3-oxopropanoate With (hydroxy(tosyloxy)iodo)benzene in acetonitrile
T=20 - 80°C; 2.33333 h;
2: thiourea in acetonitrile
T=80°C; 16 h;
参考文献
Korsager, Signe; Nielsen, Dennis U.; Taaning, Rolf H.; Skrydstrup, Troels
Angewandte Chemie - International Edition, 2013 , vol. 52, # 37 p. 9763 - 9766
Angew. Chem., 2013 , vol. 125, # 37 p. 9945 - 9948
反应条件
ethanol
anschliessend mit wss. NaOH;
参考文献
Kipnis et al.
Journal of the American Chemical Society, 1949 , vol. 71, p. 3570
反应条件
sodium methylate in methanol
T=60°C; 0.5 h;
参考文献
Ravi; Mathew; Padmanabhan; Unny; Sivaprasad
Journal of Labelled Compounds and Radiopharmaceuticals, 2006 , vol. 49, # 4 p. 339 - 343
反应条件
Behandeln des Reaktionsgemisches mit wss.Natriumcarbonat-Loesung;
参考文献
Bordwell; Andersen
Journal of the American Chemical Society, 1953 , vol. 75, p. 4959,4961
参考文献
Thomas,J.; Baker,W.A.
Journal of Pharmacy and Pharmacology, 1960 , vol. 12, p. 460 - 465
