17356-08-0合成路线 （共 1741 条）
反应条件
in ethanol
T=100°C; sealed capillaries, other temperature (70, 80, 90 deg C), lgA, activation energy; Rate constant;
参考文献
Tkachenko, S. E.; Sal'nikov, D. I.; Lys, Ya. I.; Fedoseev, V. M.; Zhurilin, V. S.
Journal of Organic Chemistry USSR (English Translation), 1983 , vol. 19, # 5 p. 878 - 884
Zhurnal Organicheskoi Khimii, 1983 , vol. 19, # 5 p. 988 - 995
反应条件
in ethanol
1 h; Heating;
参考文献
Lee, Young Bok; Park, Myung Hee; Folk, J. E.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 16 p. 3053 - 3061
参考文献
Doherty et al.
Journal of the American Chemical Society, 1957 , vol. 79, p. 5667,5670
Full Text Show Details
Clinton et al.
Journal of the American Chemical Society, 1948 , vol. 70, p. 950,952
反应条件
in acetone
T=40°C; 2.5 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; MACIKENAS, Dainius
Patent: WO2009/76200 A2, 2009 ;
Location in patent: Page/Page column 55-56 ;
参考文献
Griffin; Hey
Journal of the Chemical Society, 1952 , p. 3334,3337
反应条件
1: 1-methoxy-2-oxo-propane With bromine in methanol
T=0 - 20°C;
2: thiourea in methanol
T=20°C; Reflux;
参考文献
AMGEN INC.; ZENG, Qingping; YUAN, Chester Chenguang; YAO, Guomin; WANG, Xianghong; TADESSE, Seifu; ST. JEAN, JR., David J.; REICHELT, Andreas; LIU, Qingyian; HONG, Fang-Tsao; HAN, Nianhe; FOTSCH, Christopher H.; DAVIS, Carl D.; BOURBEAU, Matthew P.; ASHTON, Kate S.; ALLEN, John G.
Patent: WO2010/83246 A1, 2010 ;
Location in patent: Page/Page column 96-97 ;
反应条件
in methanol
Heating / reflux;
参考文献
Gubler, Marcel; Haap, Wolfgang; Hebeisen, Paul; Kitas, Eric A.; Kuhn, Bernd; Minder, Rudolf E.; Schott, Brigitte; Wessel, Hans P.
Patent: US2007/281979 A1, 2007 ;
Location in patent: Page/Page column 22 ;
反应条件
in methanol
2 h; Heating / reflux;
参考文献
AMGEN INC.
Patent: US2007/173506 A1, 2007 ;
Location in patent: Page/Page column 35 ;
参考文献
Saldabol,N.O. et al.
J. Gen. Chem. USSR (Engl. Transl.), 1964 , vol. 34, # 5 p. 1598 - 1601,1608 - 1610
反应条件
bromine in chloroform
参考文献
Saldabol,N.O. et al.
J. Gen. Chem. USSR (Engl. Transl.), 1964 , vol. 34, # 5 p. 1598 - 1601,1608 - 1610
