17356-08-0合成路线 （共 1741 条）
反应条件
in ethanol 1.5 h; Heating;
参考文献
Aloup, Jean-Claude; Bouchaudon, Jean; Farge, Daniel; James, Claude; Deregnaucourt, Jean; Hardy-Houis, Monique
Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 24 - 29
反应条件
1: methylglyoxylate methanol hemiacetal; N,N-dimethyl-formamide dimethyl acetal T=110°C; 3 - 4 h; 2: thiourea With sodium methylate in methanol T=85°C; 3 - 4 h; 3: propyl bromide T=65°C; 1.16667 - 1.25 h; Heating / reflux;
参考文献
SmithKline Beecham Corporation
Patent: US6335340 B1, 2002 ;
Location in patent: Example 23 ;
反应条件
hydrogenchloride in methanol
参考文献
Martin,T.A. et al.
Journal of Medicinal Chemistry, 1968 , vol. 11, # 3 p. 625 - 627
反应条件
in 1,4-dioxane; ethanol Heating;
参考文献
De Cat,A. et al.
Journal of Organic Chemistry, 1965 , vol. 30, p. 1498 - 1502
反应条件
solid-phase synthesis; Yield given. Multistep reaction;
参考文献
Josey, John A.; Tarlton, Catherine A.; Payne, Courtney E.
Tetrahedron Letters, 1998 , vol. 39, # 33 p. 5899 - 5902
参考文献
Lansbury,P.T. et al.
Journal of the American Chemical Society, 1970 , vol. 92, # 19 p. 5649 - 5657
参考文献
Somei, Masanori; Yamada, Yoshikazu; Kitagawa, Keiichi; Sugaya, Katsuko; Tomita, Yayoi; et. al
Heterocycles, 1997 , vol. 45, # 3 p. 434 - 438
反应条件
ethanol; sodium 5 h; Heating;
参考文献
Mai, Antonello; Artico, Marino; Sbardella, Gianluca; Quartarone, Silvana; Massa, Silvio; Loi, Anna G.; De Montis, Antonella; Scintu, Franca; Putzolu, Monica; La Colla, Paolo
Journal of Medicinal Chemistry, 1997 , vol. 40, # 10 p. 1447 - 1454
反应条件
acetic acid in ethanol 6 h; Heating;
参考文献
Kassem, Emad M. M.; Michael, Josephine M.; El-Masry, A. H.
Pakistan Journal of Scientific and Industrial Research, 1995 , vol. 38, # 11-12 p. 424 - 427
参考文献
Obushak; Matiichuk; Ganushchak
Russian Journal of Organic Chemistry, 1997 , vol. 33, # 7 p. 1010 - 1013
