17356-08-0合成路线 （共 1741 条）
反应条件
in ethanol 4 h; Heating;
参考文献
Wyrick; Hall; Dubey
Journal of Pharmaceutical Sciences, 1984 , vol. 73, # 3 p. 374 - 377
反应条件
hydrogenchloride in water 168 h; Heating;
参考文献
Lee, Ikchoon; Kang, Han Keun; Lee, Hai Whang
Journal of the American Chemical Society, 1987 , vol. 109, # 24 p. 7472 - 7477
反应条件
iodic acid in water T=25°C; 0.666667 h; different ratios of HIO3, reagent and reaction times; Rate constantProduct distributionMechanism;
参考文献
Rabai, Gyula; Beck, Mihaly T.
Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999), 1985 , p. 1669 - 1672
反应条件
1: 3-methoxy-2-propenenitrile With bromine in acetonitrile T=0°C; 0.333333 h; 2: With water in acetonitrile 1 h; Cooling; 3: thiourea With sodium acetate in acetonitrile T=0 - 60°C;
参考文献
Institut Pasteur De Lille; Centre National De La Recherche Scientifique; Universite De Lille 2, Universite Du Droit Et De La Sante; Institut National De La Sante Et De La Recherche Medicale (Inserm)
Patent: US2011/136823 A1, 2011 ;
Location in patent: Page/Page column 43-44 ;
反应条件
1: 2,3-dibromo-3-methoxy-propionitrile With sodium acetate in water; acetonitrile 0.25 h; 2: thiourea in water; acetonitrile T=15°C; 1.5 h; 3: With sodium hydroxide; sodium acetate more than 3 stages;
参考文献
Zhao, Matthew M.
Patent: US2004/10150 A1, 2004 ;
Location in patent: Page 5-6 ;
反应条件
in water T=150°C; 5 h;
参考文献
Li, Song; Zhao, Guoming; Xia, Guangqiang; Wang, Lili; Zheng, Zhibing; Xie, Yunde; Zhong, Wu; Xiao, Junhai; Li, Xingzhou; Cui, Hao
Patent: US2010/87448 A1, 2010 ;
Location in patent: Page/Page column 21 ;
反应条件
1: in water; acetonitrile T=5 - 10°C; 2 h; 2: With sodium acetate in water; acetonitrile T=60°C; 3 h;
参考文献
Zhao, Matthew; Yin, Jingjun; Huffman, Mark A.; McNamara, James M.
Tetrahedron, 2006 , vol. 62, # 6 p. 1110 - 1115
参考文献
Larsen; Connell; Cudahy; Evans; May; Meglasson; O'Sullivan; Schostarez; Sih; Stevens; Tanis; Tegley; Tucker; Vaillancourt; Vidmar; Watt; Yu
Journal of Medicinal Chemistry, 2001 , vol. 44, # 8 p. 1217 - 1230
反应条件
in water T=25°C; Rate constant;
参考文献
Kavalek, Jaromir; Said-El-Bahaie; Sterba, Vojeslav
Collection of Czechoslovak Chemical Communications, 1980 , vol. 45, # 1 p. 263 - 268
反应条件
Irradiationmicrowave;
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 37, # 1 p. 84
