17356-08-0合成路线 （共 1741 条）
反应条件
in toluene T=100°C; 1 h;
参考文献
BAYER PHARMACEUTICALS CORPORATION
Patent: WO2004/11446 A1, 2004 ;
Location in patent: Page 90 ;
反应条件
N-bromosuccinmide; meta-chloroperoxybenzoic acid in benzene Heating;
参考文献
Ahluwalia, V. K.; Aggarwal, Rachna Shashibala; Chandra, R.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1989 , vol. 28, # 1-11 p. 964 - 965
反应条件
pyridine in ethanol 5 h;
参考文献
Chande, Madhukar S.; Bhandari, Jayesh D.; Karyekar, Anita S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1995 , vol. 34, # 11 p. 985 - 989
反应条件
hydrogenchloride in ethanol T=20°C; 24 h;
参考文献
de Toledo, Juliano S.; Junior, Paulo E. S.; Manfrim, Viviane; Pinzan, Camila F.; de Araujo, Alexandre S.; Cruz, Angela K.; Emery, Flavio S.
Chemical Biology and Drug Design, 2013 , vol. 81, # 6 p. 749 - 756
反应条件
1: 3-methoxy-2-propenenitrile With sodium hydroxide; bromine in water; acetonitrile T=5 - 10°C; 1.33333 h; 2: thiourea With sodium acetate in water; acetonitrile T=10 - 15°C; 2.25 h; 3: sodium acetate With sodium hydroxide more than 3 stages;
参考文献
Larsen, Robert D.; King, Anthony On-Ping
Patent: US2004/23977 A1, 2004 ;
Location in patent: Page/Page column 7; 8 ;
US 20040023977 A1
反应条件
bromine in water 0.666667 h; Heating;
参考文献
Geronikaki; Theophilidis
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 7 p. 709 - 716
反应条件
toluene-4-sulfonic acid in water Heating;
参考文献
Diener, Heinz; Guelec, Bilge; Skrabal, Peter; Zollinger, Heinrich
Helvetica Chimica Acta, 1989 , vol. 72, p. 800 - 805
参考文献
Akiyoshi; Okuno
Journal of the American Chemical Society, 1954 , vol. 76, p. 693
反应条件
Hantzsch thiazole synthesis;
参考文献
Karpov; Nazarenko; Pekarevskii; Potekhin
Russian Journal of Applied Chemistry, 2001 , vol. 74, # 6 p. 998 - 1001
反应条件
in toluene T=80°C; 2 h; Yield given;
参考文献
Wakasugi, Takashi; Miyakawa, Tadashi; Suzuki, Fukuichi; Itsuno, Shinichi; Ito, Koichi
Chemistry Letters, 1994 , # 11 p. 2039 - 2042
