17356-08-0合成路线 （共 1741 条）
反应条件
in tetrahydrofuran; dichloromethane; water T=5 - 10°C; 2.5 h;
参考文献
LUPIN LIMITED
Patent: WO2004/58695 A1, 2004 ;
Location in patent: Page 31 ;
反应条件
1: 4-chloro-2-methoxyimino-3-oxo-butyric acid With phosphorus pentachloride in dichloromethane T=-20 - 0°C; 2: C16H20N2O5S2Si in dichloromethane T=-50 - 0°C; 3: thiourea With sodium hydrogencarbonate; trifluoroacetic acid; sodium 2-ethyl hexanoate Product distribution / selectivity; more than 3 stages;
参考文献
ORCHID CHEMICALS and PHARMACEUTICALS LIMITED
Patent: WO2008/47376 A1, 2008 ;
Location in patent: Page/Page column 4; 7; 14-15 ;
反应条件
1: 4-chloro-2-methoxyimino-3-oxo-butyric acid With phosphorus pentachloride in dichloromethane T=-20 - 0°C; 2: (6R,7R)-7-amino-3-(furan-2-carbonylsulfanylmethyl)cephalosporanic acid With ammonia in tetrahydrofuran; dichloromethane; water pH=5.5 - 8.5; 3: thiourea With sodium hydrogencarbonate; trifluoroacetic acid; sodium 2-ethyl hexanoate Product distribution / selectivity; more than 3 stages;
参考文献
ORCHID CHEMICALS and PHARMACEUTICALS LIMITED
Patent: WO2008/47376 A1, 2008 ;
Location in patent: Page/Page column 4; 7; 11-12 ;
反应条件
500-900°C in NH3 stream, at 1650°C in N2 or NH3 stream;
参考文献
O'Connor, T. E.
Journal of the American Chemical Society, 1962 , vol. 84, p. 1753 - 1754
Full Text View citing articles Show Details
Gmelin Handbook: B: B-Verb.1, 1.1.1.1.2.3, page 3 - 4
反应条件
hydrogen bromide anschliessendes Verseifen mit 1.5 Mol wss.NaOH in Stickstoffatmosphaere;
参考文献
Frank; Smith
Journal of the American Chemical Society, 1946 , vol. 68, p. 2104
Full Text Show Details
Halpern; Glasser
Journal of the American Pharmaceutical Association (1912-1977), 1949 , vol. 38, p. 288
Chem.Abstr., 1949 , p. 8610
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; CLEVELAND, Thomas; MAKINGS, Lewis R.; HAMILTON, Matthew; GROOTENHUIS, Peter D.J.
Patent: WO2005/26137 A2, 2005 ;
Location in patent: Page/Page column 247-248 ;
WO 2005/026137 A2
参考文献
Bhargava; Lakhan; Tripathi
Journal of the Indian Chemical Society, 1982 , vol. 59, # 6 p. 773 - 775
反应条件
Yield given. Multistep reaction;
参考文献
Ball, Christopher P.; Barrett, Anthony G. M.; Commercon, Alain; Compere, Delphine; Kuhn, Cyrille; Roberts, Richard S.; Smith, Marie L.; Venier, Olivier
Chemical Communications, 1998 , # 18 p. 2019 - 2020
反应条件
sulfuric acid T=50°C; beim nachfolgenden Erwaermen auf 100grad;
参考文献
Macmillan; Reade
Journal of the Chemical Society, 1929 , p. 586
参考文献
Macmillan; Reade
Journal of the Chemical Society, 1929 , p. 586
