17356-08-0合成路线 （共 1741 条）
反应条件
1: (E)-N-(2-chloro-6-methylphenyl)-3-ethoxyacrylamide With N-bromosuccinmide in 1,4-dioxane; water T=-10 - 22°C; 3 h; 2: thiourea in 1,4-dioxane; water T=100°C; 2 h; 3: With ammonia in 1,4-dioxane; water T=20 - 22°C;
参考文献
WO2008/76883 A2, ;
Page/Page column 53-54 ;
WO 2008/076883 A2
反应条件
1: (E)-N-(2-chloro-6-methylphenyl)-3-ethoxyacrylamide With N-bromosuccinmide in 1,4-dioxane; water T=-10 - 22°C; 3 h; 2: thiourea in 1,4-dioxane; water T=80°C; 2 h;
参考文献
WO2005/77945 A2, ;
Page/Page column 51 ;
WO 2005/077945 A2
反应条件
1: With hydrogenchloride; acetic acid T=50 - 65°C; 11 h; Industry scale; 2: With sodium methylate in methanol pH=8 - 9; Industry scale;
参考文献
US2007/37978 A1, ;
Page/Page column 3 ;
反应条件
in 1,4-dioxane; water T=80°C; 2 h;
参考文献
Archiv der Pharmazie, , vol. 344, # 7 p. 451 - 458
反应条件
potassium tert-butylate in ethanol 0.25 h; Reflux;
参考文献
ABBVIE INC.; DEKHTYAR, Tatyana; GOMTSYAN, Arthur; MOLLA, M-Akhteruzzaman; VASUDEVAN, Anil; NG, Teresa (Iok Chan); SHAFEEV, Mikhail
Patent: WO2013/123401 A1, 2013 ;
Location in patent: Page/Page column 39 ;
参考文献
Roth, Joshua; Minond, Dmitriy; Darout, Etzer; Liu, Qin; Lauer, Janelle; Hodder, Peter; Fields, Gregg B.; Roush, William R.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 23 p. 7180 - 7184
反应条件
in ethanol T=50°C; 0.0833333 h; microwave irradiation;
参考文献
Zhu, Dongjian; Chen, Jiuxi; Xiao, Huilong; Liu, Miaochang; Ding, Jinchang; Wu, Huayue
Synthetic Communications, 2009 , vol. 39, # 16 p. 2895 - 2906
反应条件
N-bromosuccinmide; meta-chloroperoxybenzoic acid in benzene 6 h; Heating;
参考文献
Dahiya, Rajinder; Pujari, H. K.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986 , vol. 25, p. 966
反应条件
in dichloromethane; N,N-dimethyl-formamide T=25°C; 12 h; regioselective reaction;
参考文献
Donohoe, Timothy J.; Kabeshov, Mikhail A.; Rathi, Akshat H.; Smith, Ian E. D.
Synlett, 2010 , # 19 p. 2956 - 2958
反应条件
in methanol 1.5 h; Heating;
参考文献
De Kimpe, Norbert; Boelens, Mark; Declercq, Jean-Paul
Tetrahedron, 1993 , vol. 49, # 16 p. 3411 - 3424
