2-溴-1-(5-溴呋喃-2-基)-乙酮合成路线 （共 6 条）
反应条件
bromine in 1,4-dioxane; diethyl ether T=0 - 5°C;
参考文献
Boykin, David W.; Tidwell, Richard R.; Wilson, W. David; Ismail, Mohamed A.
Patent: US2005/282853 A1, 2005 ;
Location in patent: Page/Page column 15; 19 ;
反应条件
1: With diazomethyl-trimethyl-silane in tetrahydrofuran; dichloromethane T=0°C; 2.5 h; 2: With hydrogen bromide in tetrahydrofuran; dichloromethane; water T=0°C; 0.5 h;
参考文献
OXFORD GLYCOSCIENCES (UK) LTD
Patent: WO2004/13132 A1, 2004 ;
Location in patent: Page 14 ;
反应条件
1: 61 percent / N-bromosuccinimide / dimethylformamide 2: 65 percent / bromine / dioxane; diethyl ether / 0 - 5 °C View Scheme
参考文献
Ismail, Mohamed A.; Brun, Reto; Wenzler, Tanja; Tanious, Farial A.; Wilson, W. David; Boykin, David W.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 14 p. 3658 - 3664
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane 2 h; Heating;
参考文献
Laufer, Stefan; Striegel, Hans-Guenter; Neher, Karola; Zechmeister, Pia; Donat, Cornelia; Stolingwa, Katrin; Baur, Sibylle; Tries, Susanne; Kammermeier, Thomas; Dannhardt, Gerd; Kiefer, Werner
Archiv der Pharmazie, 1997 , vol. 330, # 9-10 p. 307 - 312
反应条件
pyridine; diethyl ether Behandeln des Reaktionsprodukts mit wss. Natronlauge;
参考文献
Brown
Iowa State College Journal of Science, 1937 , vol. 11, p. 221,224
反应条件
1: ethanol
2: NaNO2 / acetic acid
View Scheme
参考文献
Saldabol,N.O. et al.
Zhurnal Organicheskoi Khimii, 1979 , vol. 15, p. 2547 - 2554,2303 - 2310
