2,4-二羟基-2H-1,4-苯并噁嗪-3(4h)-酮合成路线 (共 9 条)
反应条件
T=80°C; 1 h; Pi buffer (pH 7.5);
参考文献
Nakagawa, Eri; Amano, Takashi; Hirai, Nobuhiro; Iwamura, Hajime
Phytochemistry (Elsevier), 1995 , vol. 38, # 6 p. 1349 - 1354
反应条件
diisobutylaluminium hydride in toluene
T=-78 - 0°C; 2 h;
参考文献
Sicker; Hartenstein
Synthesis, 1993 , # 8 p. 771 - 772
反应条件
silver carbonate in tetrahydrofuran; water
Ambient temperature;
参考文献
Sicker; Pratorius; Mann; Meyer
Synthesis, 1989 , # 3 p. 211 - 212
反应条件
Escherichia coli JM109 (ATCC 53323)/pGEM4Z strain; air in methanol; water
T=30°C; 24 h;
参考文献
Valle; Cabrera; Molinillo; Gomez; MacIas; Cantero
Process Biochemistry, 2011 , vol. 46, # 1 p. 358 - 364
反应条件
1: 83 percent / NaBH4 / 10percent Pd/C / dioxane; H2O / 15 - 20 °C
2: 1) BCl3, 2) Ag2CO3 / 1) CH2Cl2, - 30 deg C up to r.t, 2 h, 2) H2O, THF
View Scheme
参考文献
Atkinson, Jeffrey; Morand, Peter; Arnason, John T.; Niemeyer, Hermann M.; Bravo, Hector R.
Journal of Organic Chemistry, 1991 , vol. 56, # 5 p. 1788 - 1800
反应条件
1: LDA / toluene; hexane / 3 h / -70 °C
2: MCPBA / CH2Cl2 / 2 h / -5 °C
3: Bu4NF*3H2O / tetrahydrofuran / 2 h / 25 °C
View Scheme
参考文献
Hartenstein, Holger; Sicker, Dieter
Tetrahedron Letters, 1994 , vol. 35, # 25 p. 4335 - 4338
反应条件
1: 82 percent / 0.5 h / Heating
2: 88 percent / aq. NH4Cl, Zn / ethanol / 2 h / 30 - 40 °C
3: 96 percent / Br2 / CCl4 / 2 h / Ambient temperature; Irradiation
4: 87 percent / Ag2CO3 / tetrahydrofuran; H2O / Ambient temperature
View Scheme
参考文献
Sicker; Pratorius; Mann; Meyer
Synthesis, 1989 , # 3 p. 211 - 212
反应条件
boron trichloride; silver carbonate
1) CH2Cl2, - 30 deg C up to r.t, 2 h, 2) H2O, THF; Yield given. Multistep reaction;
参考文献
Atkinson, Jeffrey; Morand, Peter; Arnason, John T.; Niemeyer, Hermann M.; Bravo, Hector R.
Journal of Organic Chemistry, 1991 , vol. 56, # 5 p. 1788 - 1800
反应条件
2: (i) aq. NaHCO3, (ii) aq. HCl
3: (i) N,O-bis-trimethylsilanyl-acetimidate, (ii) MoO5*2DMF, (iii) Na2H2edta
View Scheme
参考文献
Matlin,S.A. et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1979 , p. 2481 - 2487