3’-甲基-2,2,2-三氟苯乙酮合成路线 （共 9 条）
反应条件
1: 1-bromo-3-methyl-benzene With magnesium in diethyl ether 1 h; Heating; 2: trifluoroacetic acid in diethyl ether 2 h; Heating; Further stages.;
参考文献
Doucet-Personeni; Bentley; Fletcher; Kinkaid; Kryger; Pirard; Taylor; Viner; Silman; Sussman; Greenblatt; Lewis
Journal of Medicinal Chemistry, 2001 , vol. 44, # 20 p. 3203 - 3215
反应条件
1: 1-bromo-3-methyl-benzene With iodine; magnesium in tetrahydrofuran 2 h; Heating; 2: N-(trifluoroacetyl)piperidine T=0 - 20°C; 2 h;
参考文献
Schenck, Hilary A.; Lenkowski, Paul W.; Choudhury-Mukherjee, Indrani; Ko, Seong-Hoon; Stables, James P.; Patel, Manoj K.; Brown, Milton L.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 5 p. 979 - 993
反应条件
1: in dichloromethane T=20°C; Diels-Alder reaction; 2: With 1,8-diazabicyclo[5.4.0]undec-7-ene in dichloromethane T=20°C; 3: With air Title compound not separated from byproducts;
参考文献
Krasovsky, Arkady L; Nenajdenko, Valentine G; Balenkova, Elizabeth S
Tetrahedron, 2001 , vol. 57, # 1 p. 201 - 209
反应条件
1: in dichloromethane T=20°C; Diels-Alder reaction; 2: With 1,8-diazabicyclo[5.4.0]undec-7-ene in dichloromethane T=20°C; 3: With air Title compound not separated from byproducts;
参考文献
Krasovsky, Arkady L; Nenajdenko, Valentine G; Balenkova, Elizabeth S
Tetrahedron, 2001 , vol. 57, # 1 p. 201 - 209
反应条件
in diethyl ether Heating;
参考文献
Wagner, Peter J.; Lam, Henry M. H.
Journal of the American Chemical Society, 1980 , vol. 102, # 12 p. 4167 - 4172
反应条件
in tetrahydrofuran; diethyl ether 2 h; Heating;
参考文献
Kabachnik, M. I.; Zakharov, L. S.; Goryunov, E. I.; Kudryavtsev, I. Yu.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1989 , vol. 38, # 7.2 p. 1522 - 1526
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1989 , # 7 p. 1660 - 1664
参考文献
Murata; Goto; Fujiyama; Mishima; Fujio; Tsuno
Bulletin of the Chemical Society of Japan, 1990 , vol. 63, # 4 p. 1129 - 1137
反应条件
(i) Mg, (ii) /BRN= 742035/; Multistep reaction;
参考文献
Lapkin,I.I. et al.
Journal of Organic Chemistry USSR (English Translation), 1970 , vol. 6, p. 233 - 235
Zhurnal Organicheskoi Khimii, 1970 , vol. 6, # 2 p. 241 - 243
反应条件
sodium tetrahydroborate in methanol; water T=20°C; 5 h;
参考文献
Kabachnik, M. I.; Zakharov, L. S.; Goryunov, E. I.; Kudryavtsev, I. Yu.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1989 , vol. 38, # 7.2 p. 1522 - 1526
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1989 , # 7 p. 1660 - 1664
