3-(4-氟苯基)-5-甲基-4-异恶唑羧酸合成路线 （共 8 条）
反应条件
sodium hydroxide in ethanol T=20 - 30°C; 5 h;
参考文献
Hoffmann-La Roche Inc.; Dott, Pascal; Grassmann, Olaf; Kammerer, Michael; Manns, Joachim; Schwitter, Urs; Thomas, Andrew; Wyttenbach, Nicole
Patent: US2013/172329 A1, 2013 ;
Location in patent: Paragraph 0258 ;
反应条件
1: N-chlorosuccinimide / dimethylformamide / Ambient temperature 2: 38 percent / Et3N / diethyl ether / 0.75 h 3: conc. aq. HCl, CH3COOH / 72 h / Heating View Scheme
参考文献
Journal of Agricultural and Food Chemistry, , vol. 43, # 1 p. 219 - 228
反应条件
1: 38 percent / Et3N / diethyl ether / 0.75 h 2: conc. aq. HCl, CH3COOH / 72 h / Heating View Scheme
参考文献
Journal of Agricultural and Food Chemistry, , vol. 43, # 1 p. 219 - 228
反应条件
1.1: hydroxylamine hydrochloride / water / 0 - 25 °C 2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 1.5 h / 20 °C 2.2: 28 h / 20 °C 3.1: sodium hydroxide / ethanol / 5 h / 20 - 30 °C View Scheme
反应条件
hydrogenchloride; acetic acid 72 h; Heating;
参考文献
Journal of Agricultural and Food Chemistry, , vol. 43, # 1 p. 219 - 228
反应条件
(i) Na, MeOH, (ii) /BRN= 2209129/, (iii) aq. KOH, EtOH; Multistep reaction;
参考文献
Journal of the Chemical Society, , p. 5838 - 5845
反应条件
oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane
1 h; Heating;
参考文献
Hamper, Bruce C.; Leschinsky, Kindrick L.; Massey, Steven S.; Bell, Crystal L.; Brannigan, Lawrence H.; Prosch, S. Douglas
Journal of Agricultural and Food Chemistry, 1995 , vol. 43, # 1 p. 219 - 228
反应条件
C46H48N6O5Pd; potassium acetate in N,N-dimethyl acetamide
T=160°C; 24 h; Inert atmosphere;
参考文献
Nandi, Debkumar; Jhou, Yang-Ming; Lee, Jhen-Yi; Kuo, Bing-Chiuan; Liu, Chien-Yu; Huang, Pei-Wen; Lee, Hon Man
Journal of Organic Chemistry, 2012 , vol. 77, # 20 p. 9384 - 9390
