sodium methylate T=50°C; 3 h;

1: 65.8 percent / 0.05 N methanolic sodium methoxide / 3 h / 50 °C 2: 78 percent / phosphoryl chloride, triethylphosphate / 12 h / 0 °C 3: 1.) N,N'carbonyldiimidazole, 2.) tri-n-butylammonium pyrophosphate / 1.) DMF, RT, 3.5 h, 2.) DMF, RT, 24 h View Scheme