1-十六酰-sn-丙三醇-磷酸胆碱合成路线 （共 29 条）
反应条件
1: L-alpha-glycerylphosphorylcholine With di(n-butyl)tin oxide in isopropyl alcohol 1 h; Heating; 2: n-hexadecanoyl chloride With TEA in isopropyl alcohol T=25°C; 0.25 h; Further stages.;
参考文献
Fasoli, Ezio; Arnone, Alberto; Caligiuri, Antonio; D'Arrigo, Paola; De Ferra, Lorenzo; Servi, Stefano
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 15 p. 2974 - 2978
反应条件
1: L-alpha-glycerylphosphorylcholine With di(n-butyl)tin oxide in methanol 1.5 h; Heating / reflux; 2: n-hexadecanoyl chloride With triethylamine in WA T=25°C; Product distribution / selectivity;
参考文献
Chem SPA
Patent: US2006/79703 A1, 2006 ;
Location in patent: Page/Page column 4 ;
反应条件
hydrogenchloride in 1,4-dioxane T=20°C; 2 h;
参考文献
Rosseto, Renato; Bibak, Niloufar; Hajdu, Joseph
Tetrahedron Letters, 2004 , vol. 45, # 39 p. 7371 - 7373
反应条件
hexadecanoic acid in N,N-dimethyl-formamide T=80°C; 26 h;
参考文献
Lindberg, Jan; Ekeroth, Johan; Konradsson, Peter
Journal of Organic Chemistry, 2002 , vol. 67, # 1 p. 194 - 199
反应条件
Tris-HCl buffer; calcium chloride; phospholipase A2 in diethyl ether; ethanol T=20°C; deacylation; pH=8.0; 7 h;
参考文献
Akama, Kazuhiro; Yano, Yoshihiro; Tokuyama, Satoru; Hosoi, Fumio; Omichi, Hideki
Journal of Materials Chemistry, 2000 , vol. 10, # 5 p. 1047 - 1059
反应条件
1: L-alpha-glycerylphosphorylcholine With di(n-butyl)tin oxide in methanol 1.5 h; Heating / reflux; 2: n-hexadecanoyl chloride With triethylamine in isopropyl alcohol T=25°C; Product distribution / selectivity;
参考文献
US2006/79703 A1, ;
Page/Page column 3 ;
反应条件
1: L-alpha-glycerylphosphorylcholine With di(n-butyl)tin oxide in methanol 1 - 1.5 h; Heating / reflux; 2: n-hexadecanoyl chloride With triethylamine in isopropyl alcohol T=25 - 40°C; Product distribution / selectivity;
参考文献
EP1650215 A1, ;
Page/Page column 7 ;
反应条件
hydrogen; palladium on activated charcoal in methanol; chloroform 4 h; Ambient temperature;
参考文献
Tetrahedron Asymmetry, , vol. 8, # 3 p. 451 - 458
反应条件
1: 92 percent / pyridinium p-toluenesulfonate / CHCl3 / 1 h / 20 °C 2: 62 percent / NaBH4 / 1,2-dimethoxy-ethane / 1 h / 20 °C 3: Et3N / benzene 4: acetonitrile / 24 h / 65 °C 5: 98 percent / HCl / dioxane; H2O View Scheme
参考文献
Tetrahedron Letters, , vol. 45, # 39 p. 7371 - 7373
反应条件
1: 83 percent / NaBH4 / methanol / 4 h / Ambient temperature 2: 1.) Et3N, 2.) H2O / 1.) CH2Cl2, 0-5 deg C, 4 h, 2.) RT, 30 min 3: 68 percent / ethanol; CHCl3 / 60 h / 60 - 70 °C 4: H2 / 10percent Pd/C / CHCl3; methanol / 4 h / Ambient temperature View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 8, # 3 p. 451 - 458
