1-[4-(三氟甲基)苯基]乙醇合成路线 （共 66 条）
反应条件
(S,S)-RuCl2(2,2'-bis(di-3,5-xylylphosphino)-1,1'-binaphthyl)(1,1-dianisyl-2-isopropyl-1,2-ethylenediamine); potassium tert-butylate; hydrogen in isopropyl alcohol T=26 - 30°C; P=7600 Torr; 20 h;
参考文献
Ohkuma; Koizumi; Doucet; Pham; Kozawa; Murata; Katayama; Yokozawa; Ikariya; Noyori
Journal of the American Chemical Society, 1998 , vol. 120, # 51 p. 13529 - 13530
反应条件
dimethylsulfide borane complex; 2-methyl oxaborolidine in tetrahydrofuran 0.25 h; cooling; Title compound not separated from byproducts;
参考文献
Tagat; Steensma; McCombie; Nazareno; Lin; Neustadt; Cox; Xu; Wojcik; Murray; Vantuno; Baroudy; Strizki
Journal of Medicinal Chemistry, 2001 , vol. 44, # 21 p. 3343 - 3346
反应条件
Candida antarctica lipase B; (η5-C5Ph5)Ru(CO)2Cl; potassium tert-butylate; sodium carbonate in tetrahydrofuran; toluene T=20°C; 24 h;
参考文献
Martin-Matute, Belen; Edin, Michaela; Bogar, Krisztian; Kaynak, F. Betuel; Baeckvall, Jan-E.
Journal of the American Chemical Society, 2005 , vol. 127, # 24 p. 8817 - 8825
反应条件
1: trimethylaluminum With 1,4-diaza-bicyclo[2.2.2]octane in toluene T=0°C; 2: 4-trifluoromethyl-benzaldehyde With [(R)-1,1'-binaphthyl-2,2'-diyldioxy]{bis[(S)-(1-phenylethyl)]amino}phosphine; bis(acetylacetonate)nickel(II) in tetrahydrofuran T=5°C; 1 h; Title compound not separated from byproducts;
参考文献
Angewandte Chemie - International Edition, , vol. 44, # 15 p. 2232 - 2234
反应条件
1: With (2R,3S,3aS,4aR,6R,8aS)-2-isopropyl-6,9,9-trimethyl-3-phenyldecahydro-4aH-pyrrolo[2,1-b][1,3]benzoxazin-3-ol in hexane; toluene T=-20 - 20°C; 30 h; Inert atmosphere; 2: With ammonium chloride in hexane; water; toluene Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Infante, Rebeca; Nieto, Javier; Andrs, Celia
Synthesis, 2012 , vol. 44, # 9 p. 1343 - 1348
反应条件
bis(acetylacetonate)nickel(II); C64H93NO8P2 in tetrahydrofuran T=5°C; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Tetrahedron Letters, , vol. 50, # 31 p. 4495 - 4497
反应条件
potassium fluoride; trichlorosilane; dihydrogen peroxide; potassium hydrogencarbonate; bis(η3-allyl-μ-chloropalladium(II)); (S)-2-diphenylphosphino-1,1'-binaphthyl 1) 0 deg C, 5 d; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of the Chemical Society, Chemical Communications, , # 15 p. 1533 - 1534
反应条件
(1S,2R)-(-)-2-(N,N-di-n-butylamino)-1-phenylpropan-1-ol in hexane T=0°C; 214 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of Fluorine Chemistry, , vol. 59, # 1 p. 5 - 8
反应条件
1: With benzo[1,3,2]dioxaborole; rhodium complex 8 in toluene T=20°C; Addition; Hydroboration; 2 h; 2: With sodium hydroxide; water; dihydrogen peroxide in toluene T=20°C; Oxidation; 2 h; Title compound not separated from byproducts;
参考文献
Chemistry - A European Journal, , vol. 5, # 4 p. 1320 - 1330
反应条件
palladium diacetate; oxygen; (-)-sparteine in 1,2-dichloro-ethane T=60°C; Title compound not separated from byproducts.;
参考文献
Journal of the American Chemical Society, , vol. 123, # 30 p. 7475 - 7476
