1-[4-(三氟甲基)苯基]乙醇合成路线 （共 66 条）
反应条件
1: methylmagnesium bromide With titanium(IV) isopropylate; (Sa)-2'-[(R)-hydroxy(phenyl)methyl]-(1,1'-binaphthalen)-2-ol in toluene T=-40°C; 0.166667 h; Inert atmosphere; 2: 4-trifluoromethyl-benzaldehyde in toluene T=-40°C; Grignard reaction; 4 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
European Journal of Organic Chemistry, , # 34 p. 6851 - 6855
反应条件
1: With (Sa)-2'-[(R)-hydroxy(phenyl)methyl]-(1,1'-binaphthalen)-2-ol; titanium (IV) isopropoxide in toluene T=-40°C; 1 h; Inert atmosphere; 2: With hydrogenchloride in water Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
European Journal of Organic Chemistry, , # 20 p. 3732 - 3736
反应条件
1.1: Mg / tetrahydrofuran / 0 - 20 °C 1.2: 91 percent / tetrahydrofuran / -78 - 20 °C 2.1: 80 percent / aq. NaOH; aq. H2O2 / diethyl ether / 16 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 65, # 23 p. 8123 - 8125
反应条件
C50H42ClN2O3Ru in chloroform T=25°C; Molecular sieveResolution of racemate; Kinetics; enantioselective reaction;
参考文献
Mizoguchi, Hirotaka; Uchida, Tatsuya; Katsuki, Tsutomu
Angewandte Chemie - International Edition, 2014 , vol. 53, # 12 p. 3178 - 3182
Angew. Chem., 2014 , vol. 126, # 12 p. 3242 - 3246,5
反应条件
lithium aluminium tetrahydride in diethyl ether 6 h; Heating;
参考文献
Tetrahedron Asymmetry, , vol. 7, # 11 p. 3285 - 3294
参考文献
Organic Letters, , vol. 9, # 9 p. 1659 - 1661
反应条件
air; cells of Geotrichum candidum IFO5767 in water T=30°C; 24 h; Product distribution;
参考文献
Tetrahedron Asymmetry, , vol. 12, # 22 p. 3147 - 3153
反应条件
Candida antarctica lipase B in tert-butyl methyl ether 16 h; Enzymatic reaction; optical yield given as percent ee;
参考文献
Organic Process Research and Development, , vol. 13, # 4 p. 706 - 709
反应条件
1: With Candida antarctica lipase B in tert-butyl methyl ether 16 h; Enzymatic reaction; 2: With hydrogenchloride; water in methanol optical yield given as percent ee;
参考文献
Organic Process Research and Development, , vol. 13, # 4 p. 706 - 709
反应条件
3 A molecular sieve; Humicola insolens ferulic acid esterase T=45°C; 120 h;
参考文献
Bioorganic Chemistry, , vol. 33, # 4 p. 325 - 337
