1-[4-(三氟甲基)苯基]乙醇合成路线 （共 66 条）
反应条件
Candida antarctica lipase B; (η5-C5Ph5)Ru(CO)2Cl; potassium tert-butylate; sodium carbonate in tetrahydrofuran; toluene T=20°C; 24 h;
参考文献
Martin-Matute, Belen; Edin, Michaela; Bogar, Krisztian; Kaynak, F. Betuel; Baeckvall, Jan-E.
Journal of the American Chemical Society, 2005 , vol. 127, # 24 p. 8817 - 8825
反应条件
palladium diacetate; oxygen; (-)-sparteine in 1,2-dichloro-ethane T=60°C; Title compound not separated from byproducts.;
参考文献
Sun, Wei; Wu, Xiaomei; Xia, Chungu
Helvetica Chimica Acta, 2007 , vol. 90, # 3 p. 623 - 626
反应条件
polyoxyethylene (10) cetyl ether; n-octyl beta-D-glucopyranoside; subtilisin Carlsberg; sodium carbonate in tetrahydrofuran T=20°C; 17 h; Title compound not separated from byproducts;
参考文献
Boren, Linnea; Martin-Matute, Belen; Xu, Yongmei; Cordova, Armando; Baeckvall, Jan-E.
Chemistry - A European Journal, 2006 , vol. 12, # 1 p. 225 - 232
反应条件
4 A molecular sieve; subtilisin Carlsberg in 1,4-dioxane T=30°C; 48 h;
参考文献
Savile, Christopher K.; Kazlauskas, Romas J.
Journal of the American Chemical Society, 2005 , vol. 127, # 35 p. 12228 - 12229
反应条件
1-[4-(trifluoromethyl)phenyl]ethan-1-one; immobilized Candida antarctica Lipase B; potassium carbonate; chiral ruthenium-based in toluene T=70°C; P=150.012 Torr; 30 h;
参考文献
van Nispen, Sjoerd F.G.M.; van Buijtenen, Jeroen; Vekemans, Jef A.J.M.; Meuldijk, Jan; Hulshof, Lumbertus A.
Tetrahedron Asymmetry, 2006 , vol. 17, # 15 p. 2299 - 2305
反应条件
1: 76 percent / pyridine / CH2Cl2 2: Lipase from Burkholderia cepacia; CaCl2; aq. BES buffer / acetonitrile / 48 h / 30 °C / pH 7.2 View Scheme
参考文献
Naemura, Koichiro; Murata, Masaki; Tanaka, Rie; Yano, Masashi; Hirose, Keiji; Tobe, Yoshito
Tetrahedron Asymmetry, 1996 , vol. 7, # 11 p. 3285 - 3294
反应条件
Candida antartica lipase B in various solvent(s) T=40°C; P=67505.4 Torr; 2 h;
参考文献
Matsuda, Tomoko; Tsuji, Kazuhiko; Kamitanaka, Takashi; Harada, Tadao; Nakamura, Kaoru; Ikariya, Takao
Chemistry Letters, 2005 , vol. 34, # 8 p. 1102 - 1103
反应条件
C50H42ClN2O3Ru in chloroform T=25°C; Molecular sieveResolution of racemate; Kinetics; enantioselective reaction;
参考文献
Mizoguchi, Hirotaka; Uchida, Tatsuya; Katsuki, Tsutomu
Angewandte Chemie - International Edition, 2014 , vol. 53, # 12 p. 3178 - 3182
Angew. Chem., 2014 , vol. 126, # 12 p. 3242 - 3246,5
反应条件
air; cells of Geotrichum candidum IFO5767 in water T=30°C; 24 h; Product distribution;
参考文献
Xu, Yulong; Cheng, Tanyu; Long, Jie; Liu, Ketang; Qian, Qingqian; Gao, Fei; Liu, Guohua; Li, Hexing
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 17 p. 3250 - 3258
反应条件
Candida antarctica lipase B in tert-butyl methyl ether 16 h; Enzymatic reaction; optical yield given as percent ee;
参考文献
Brossat, Maude; Moody, Thomas S.; Nanteuil, Florian De; Taylor, Stephen J.C.; Vaughan, Fatima
Organic Process Research and Development, 2009 , vol. 13, # 4 p. 706 - 709
