1-[4-(三氟甲基)苯基]乙醇合成路线 （共 66 条）
反应条件
air; cells of Geotrichum candidum IFO5767 in water T=30°C; 24 h; Product distribution;
参考文献
Xu, Yulong; Cheng, Tanyu; Long, Jie; Liu, Ketang; Qian, Qingqian; Gao, Fei; Liu, Guohua; Li, Hexing
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 17 p. 3250 - 3258
反应条件
Candida antarctica lipase B in tert-butyl methyl ether 16 h; Enzymatic reaction; optical yield given as percent ee;
参考文献
Brossat, Maude; Moody, Thomas S.; Nanteuil, Florian De; Taylor, Stephen J.C.; Vaughan, Fatima
Organic Process Research and Development, 2009 , vol. 13, # 4 p. 706 - 709
反应条件
1: With Candida antarctica lipase B in tert-butyl methyl ether 16 h; Enzymatic reaction; 2: With hydrogenchloride; water in methanol optical yield given as percent ee;
参考文献
Brossat, Maude; Moody, Thomas S.; Nanteuil, Florian De; Taylor, Stephen J.C.; Vaughan, Fatima
Organic Process Research and Development, 2009 , vol. 13, # 4 p. 706 - 709
反应条件
3 A molecular sieve; Humicola insolens ferulic acid esterase T=45°C; 120 h;
参考文献
Hatzakis, Nikos S.; Smonou, Ioulia
Bioorganic Chemistry, 2005 , vol. 33, # 4 p. 325 - 337
反应条件
1: 60 percent / P2O5 / benzene / 4 h / Heating
2: Br2 / diethyl ether / 2 h / -10 °C
3: 50 percent / KOH / H2O; diethyl ether / 180 - 220 °C
4: 1.) Li, Fe(NO3)3 / 1.) liq.NH3, HMPA, 30 min; 2.) 6 h
View Scheme
参考文献
Mesnard, Danielle; Bernadou, Francoise; Miginiac, Leone
Journal of Chemical Research, Miniprint, 1981 , # 9 p. 3216 - 3245
反应条件
1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 24 h / 25 °C
2: iodine / neat (no solvent) / 2 h / 85 °C
View Scheme
参考文献
Jereb, Marjan; Vrazic, Dejan
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 12 p. 1978 - 1999
