3,5-二氯-2,4,6-三氟吡啶合成路线 （共 48 条）
反应条件
potassium fluoride; tetra-phenylphosphonium bromide in sulfolane T=200°C; Fluorination; 7 h;
参考文献
Journal of Fluorine Chemistry, , vol. 101, # 1 p. 45 - 60
反应条件
Catalyst M-Chromium oxide T=520°C; Further byproducts given. Title compound not separated from byproducts;
参考文献
Journal of Fluorine Chemistry, , vol. 53, # 1 p. 33 - 42
反应条件
Catalyst M-Chromium oxide T=520°C;
参考文献
Journal of Fluorine Chemistry, , vol. 53, # 1 p. 33 - 42
反应条件
in diethyl ether
91 h; Irradiation;
参考文献
Barlow, Michael G.; Haszeldine, Robert N.; Langridge, John R.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 2520 - 2522
反应条件
1: 85 percent / HCOONH4 / Pd/C / octan-1-ol / 25 °C
2: 91 percent / BuLi / tetrahydrofuran; hexane / 1 h / -75 °C
3: 98 percent / hydrazine monohydrate / tetrahydrofuran / 2 h / 50 °C
4: 85 percent / tetrabutylammonium fluoride trihydrate / tetrahydrofuran / 25 °C
View Scheme
参考文献
Bobbio, Carla; Rausis, Thierry; Schlosser, Manfred
Chemistry - A European Journal, 2005 , vol. 11, # 6 p. 1903 - 1910
反应条件
1: 99 percent / NaOMe / 48 h / Heating
2: 25 percent / LiAlH4 / diethyl ether / 6 h / Heating
View Scheme
参考文献
Chambers, Richard D.; Khalil, Ali; Murray, Christopher B.; Sandford, Graham; Batsanov, Andrei S.; Howard, Judith A.K.
Journal of Fluorine Chemistry, 2005 , vol. 126, # 7 p. 1002 - 1008
反应条件
Catalyst M-Chromium oxide
T=520°C; Further byproducts given. Title compound not separated from byproducts;
参考文献
Weigert, F. J.
Journal of Fluorine Chemistry, 1991 , vol. 53, # 1 p. 33 - 42
反应条件
Catalyst M-Chromium oxide
T=520°C;
参考文献
Weigert, F. J.
Journal of Fluorine Chemistry, 1991 , vol. 53, # 1 p. 33 - 42
反应条件
1: 98 percent / aq. NH4OH / 20 °C
2: 33 percent / Et3N; H2 / 10 percent Pd/C / ethanol / 18 h / 2585.74 Torr
3: 76 percent / conc. H2SO4; KNO3 / 0 - 20 °C
4: 89 percent / conc. H2SO4 / 20 °C
View Scheme
参考文献
Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000
反应条件
1: 98 percent / aq. NH4OH / 20 °C
2: 33 percent / Et3N; H2 / 10 percent Pd/C / ethanol / 18 h / 2585.74 Torr
3: 76 percent / conc. H2SO4; KNO3 / 0 - 20 °C
4: 89 percent / conc. H2SO4 / 20 °C
5: 92 percent / H2 / Raney Ni / ethanol
View Scheme
参考文献
Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000
