3,5-二氯-2,4,6-三氟吡啶合成路线 （共 48 条）
反应条件
1: 98 percent / aq. NH4OH / 20 °C
2: 33 percent / Et3N; H2 / 10 percent Pd/C / ethanol / 18 h / 2585.74 Torr
3: 76 percent / conc. H2SO4; KNO3 / 0 - 20 °C
4: 89 percent / conc. H2SO4 / 20 °C
5: 92 percent / H2 / Raney Ni / ethanol
View Scheme
参考文献
Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000
反应条件
1: 98 percent / aq. NH4OH / 20 °C
2: 57 percent / Et3N; H2 / 10 percent Pd/C / ethanol / 18 h / 2585.74 Torr
View Scheme
参考文献
Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000
反应条件
zinc
8 h; Product distribution; Further Variations:Reagentstime;
参考文献
Selivanova, Galina A.; Gurskaya, Larisa Yu.; Pokrovskii, Leonid M.; Kollegov, Vitaliy F.; Shteingarts, Vitaliy D.
Journal of Fluorine Chemistry, 2004 , vol. 125, # 12 p. 1829 - 1834
反应条件
1: 98 percent / aq. NH4OH / 20 °C
2: 57 percent / Et3N; H2 / 10 percent Pd/C / ethanol / 18 h / 2585.74 Torr
3: 76.4 percent / conc. H2SO4; KNO3 / 0 - 20 °C
4: 82 percent / conc. H2SO4 / 20 °C
View Scheme
参考文献
Liu; Luo; Mozdziesz; Lin; Dutschman; Gullen; Cheng; Sartorelli
Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 12 p. 1975 - 2000
反应条件
in 1,4-dioxane
20 °C, stirring, in presence of (C2H5)3N;;
参考文献
Gmelin Handbook: F: PerFHalOrg.5, 4, page 115 - 148
反应条件
-15 to -5 °C, then 0 °C, 2 h;;
参考文献
Gmelin Handbook: F: PerFHalOrg.5, 4, page 115 - 148
反应条件
Catalyst M-Chromium oxide
T=520°C; Further byproducts given. Title compound not separated from byproducts;
参考文献
Weigert, F. J.
Journal of Fluorine Chemistry, 1991 , vol. 53, # 1 p. 33 - 42
反应条件
Catalyst M-Chromium oxide
T=520°C;
参考文献
Weigert, F. J.
Journal of Fluorine Chemistry, 1991 , vol. 53, # 1 p. 33 - 42
