4-氨基-1,2,5-噁二唑-3-甲酸乙酯合成路线 （共 5 条）
反应条件
thionyl chloride in ethanol T=0°C; 4 h; Heating / reflux;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2005/19190 A2, 2005 ;
Location in patent: Page/Page column 55 ;
WO 2005/019190 A2
反应条件
hydrogenchloride; acetic anhydride; tin(ll) chloride in acetic acid T=20 - 22°C; 48 h;
参考文献
Kulikov, A. S.; Makhova, N. N.; Godovikova, T. I.; Golova, S. P.; Khmel'nitskii, L. I.
Russian Chemical Bulletin, 1994 , vol. 43, # 4 p. 630 - 631
Izvestiya Akademi Nauk, Seriya Khimicheskaya, 1994 , # 4 p. 679 - 680
反应条件
in diethyl ether T=25°C; 48 h;
参考文献
Russian Journal of Organic Chemistry, , vol. 48, # 3 p. 475 - 475
反应条件
hydrogenchloride; sulfuric acid Heating;
参考文献
Journal of Heterocyclic Chemistry, , vol. 2, p. 253 - 255
反应条件
ammonia in ethanol T=20°C;
参考文献
Fonar; Simonov; Kravtsov; Lipkowski; Javolowski; Ganin
Journal of Structural Chemistry, 2001 , vol. 42, # 3 p. 459 - 469
