1: pig liver esterase / aq. phosphate buffer; ethanol / pH 7.4 / |Enzymatic reaction 2: triethylamine; diphenyl phosphoryl azide / 1,2-dichloro-ethane / 5 h / 20 °C / |Inert atmosphere; |Reflux 3: titanium(IV) isopropylate / toluene / 12 h / 80 °C / |Inert atmosphere 4: hydrogenchloride / water; 1,4-dioxane / 24 h / |Reflux 5: sodium hydrogencarbonate / water; 1,4-dioxane / 0.33 h / 0 °C View Scheme