3-氨基-2,4-二氯吡啶合成路线 （共 13 条）
反应条件
hydrogenchloride; tin(ll) chloride in diethyl ether T=20°C; 2 h;
参考文献
Palmer, Andreas Marc; Muench, Gabriela; Brehm, Christof; Zimmermann, Peter Jan; Buhr, Wilm; Feth, Martin Philipp; Simon, Wolfgang Alexander
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 3 p. 1511 - 1530
反应条件
sodium hydrogencarbonate in acetic acid
反应条件
in HCl (conc.); diethyl ether; water
参考文献
Amgen Inc.
Patent: US6187777 B1, 2001 ;
反应条件
1: 80 percent / POCl3 / 24 h / Heating 2: 90 percent / SnCl2*2H2O; conc. aq. HCl / diethyl ether / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 22 p. 4288 - 4312
反应条件
1: 90 percent / fuming HNO3; conc. H2SO4 / 0.5 h / 0 °C 2: 80 percent / POCl3 / 24 h / Heating 3: 90 percent / SnCl2*2H2O; conc. aq. HCl / diethyl ether / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 22 p. 4288 - 4312
反应条件
N-bromosuccinmide in N,N-dimethyl-formamide T=0°C; 0.25 h;
参考文献
Norman; Chen; Fotsch; Hale; Han; Hurt; Jenkins; Kincaid; Liu; Lu; Moreno; Santora; Sonnenberg; Karbon
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4288 - 4312
反应条件
1: 90 percent / N-bromosuccinimide / dimethylformamide / 0.25 h / 0 °C 2: 85 percent / K2CO3; Pd(PPh3)2Cl2 / dimethylformamide / 24 h / 100 °C 3: 90 percent / Et3N; Pd(PPh3)2Cl2; CuI / 4 h / 80 °C 4: 48 percent / CuI / dimethylformamide / 18 h / 100 °C View Scheme
参考文献
Norman; Chen; Fotsch; Hale; Han; Hurt; Jenkins; Kincaid; Liu; Lu; Moreno; Santora; Sonnenberg; Karbon
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4288 - 4312
反应条件
1: HCl; acetic acid; aqueous H2O2 2: sodium nitrite; copper-powder; aqueous hydrochloric acid / Diazotization View Scheme
参考文献
den Hertog et al.
Recueil des Travaux Chimiques des Pays-Bas, 1950 , vol. 69, p. 673,690
反应条件
1: 90 percent / N-bromosuccinimide / dimethylformamide / 0.25 h / 0 °C 2: 85 percent / K2CO3; Pd(PPh3)2Cl2 / dimethylformamide / 24 h / 100 °C View Scheme
参考文献
Norman; Chen; Fotsch; Hale; Han; Hurt; Jenkins; Kincaid; Liu; Lu; Moreno; Santora; Sonnenberg; Karbon
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4288 - 4312
反应条件
hydrogenchloride; dihydrogen peroxide; acetic acid
参考文献
den Hertog et al.
Recueil des Travaux Chimiques des Pays-Bas, 1950 , vol. 69, p. 673,690
