2-[2-(2-羟基乙基)苯基]乙醇合成路线 （共 14 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran Ambient temperature;
参考文献
Harvey, Ronald G.; Pataki, John; Cortez, Cecilia; Raddo, Pasquale Di; Yang, ChengXi
Journal of Organic Chemistry, 1991 , vol. 56, # 3 p. 1210 - 1217
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=5 - 10°C; 0.916667 h; 2: With water in tetrahydrofuran 3: With hydrogenchloride in tetrahydrofuran; dichloromethane pH=4 - 6;
参考文献
Abbott GmbH and Co. KG.
Patent: US2005/137186 A1, 2005 ;
Location in patent: Page/Page column 11-12 ;
反应条件
lithium aluminium tetrahydride in diethyl ether 1 h; Heating;
参考文献
Krafft, Marie E.; Schmidt, Peter
Synthetic Communications, 2002 , vol. 32, # 17 p. 2723 - 2732
反应条件
indium tribromide; 1,1,3,3-tetramethyldisiloxane in toluene T=60°C; 15 h; Inert atmosphere;
参考文献
Pehlivan, Leyla; Metay, Estelle; Delbrayelle, Dominique; Mignani, Gerard; Lemaire, Marc
European Journal of Organic Chemistry, 2012 , # 25 p. 4689 - 4693
反应条件
1: 84 percent / conc. H2SO4 / 7 h / Heating 2: 92 percent / LiAlH4 / diethyl ether / 1 h / Heating View Scheme
参考文献
Steigelmann, Oliver; Bissinger, Peter; Schmidbaur, Hubert
Angewandte Chemie, 1990 , vol. 102, # 12 p. 1473 - 1475
反应条件
1: aqueous hydrobromic acid 3: phenyl lithium; N-methyl-aniline; diethyl ether 4: H2SO4 5: acetic acid 6: tetrachloro-<1,4>benzoquinone; benzene View Scheme
参考文献
Muth et al.
Journal of the American Chemical Society, 1955 , vol. 77, p. 1006,1008
反应条件
triethylamine in dichloromethane T=0°C; 0.5 h;
参考文献
CEPHALON, INC.; PHARMACOPEIA DRUG DISCOVERY, INC.
Patent: WO2008/51547 A1, 2008 ;
Location in patent: Page/Page column 259; 314-315 ;
WO 2008/051547 A1
反应条件
1: 50 percent / Ag2CO3/celite / benzene / 68 h / Heating 2: 33 percent / aq. KOH / 0.5 h View Scheme
参考文献
Meise, Werner; Arth, Christoph
Liebigs Annalen der Chemie, 1992 , # 2 p. 163 - 166
反应条件
hydrogen bromide 5 h; Heating;
参考文献
Angewandte Chemie, , vol. 102, # 12 p. 1473 - 1475
反应条件
potassium hydroxide
T=185°C; P=60 Torr;
参考文献
Halford; Weissmann
Journal of Organic Chemistry, 1952 , vol. 17, p. 1646,1651
