1: triethylamine / acetonitrile / 4 h / 20 °C 2: H2 / Pd / acetic acid; 2-methyl-propan-2-ol; H2O View Scheme

1: triethylamine / acetonitrile / 4 h / 20 °C 2: H2 / Pd / acetic acid; 2-methyl-propan-2-ol; H2O View Scheme

hydrogenchloride Heating;

1: 75 percent / diisopropylethylamine / dimethylformamide / 12 h / Ambient temperature 2: trifluoroacetic acid / 0.67 h 3: diisopropylethylamine, 1-hydroxybenzotriazole / dimethylformamide / 12 h / Ambient temperature 4: trifluoroacetic acid / 0.67 h 5: diisopropylethylamine / dimethylformamide / 12 h / Ambient temperature View Scheme

potassium hydroxide; bis(o-nitrophenyl)phenylphosphonate; 4 A molecular sieve; trithylamine; tetrabutylammomium bromide other acids; multistep reaction;