3-氯-1-甲基-1H-吡唑-5-羧酸甲酯合成路线 （共 3 条）
反应条件
sodium hypochlorite in chloroform T=20°C; 72 h; Cooling with ice;
参考文献
NOVARTIS AG
Patent: US2012/258973 A1, 2012 ;
Location in patent: Page/Page column 52 ;
反应条件
1: 19 h / -5 - 100 °C 2: triethylamine; trichlorophosphate / chloroform / 21 h / -5 - 20 °C 3: sodium hypochlorite / chloroform / 72 h / 20 °C / Cooling with ice View Scheme
参考文献
NOVARTIS AG; BADIGER, Sangamesch; BEHNKE, Dirk; BETSCHART, Claudia; CHAUDHARI, Vinod; CHEBROLU, Murali; COSTESTA, Simona; HINTERMANN, Samuel; MEYER, Arndt; PANDIT, Chetan
Patent: WO2011/76744 A1, 2011 ;
WO 2011/076744 A1
反应条件
1: triethylamine; trichlorophosphate / chloroform / 21 h / -5 - 20 °C 2: sodium hypochlorite / chloroform / 72 h / 20 °C / Cooling with ice View Scheme
参考文献
NOVARTIS AG; BADIGER, Sangamesch; BEHNKE, Dirk; BETSCHART, Claudia; CHAUDHARI, Vinod; CHEBROLU, Murali; COSTESTA, Simona; HINTERMANN, Samuel; MEYER, Arndt; PANDIT, Chetan
Patent: WO2011/76744 A1, 2011 ;
WO 2011/076744 A1
