(R)-1-(3-吡啶基)-2-氯乙醇合成路线 （共 6 条）
反应条件
triethylamine; B-chloro-diisopinocampheylborane in tetrahydrofuran T=-25°C; 72 h;
参考文献
Sumitomo Pharmaceuticals Company, Limited
Patent: EP1514869 A1, 2005 ;
Location in patent: Page/Page column 20 ;
反应条件
formic acid; triethylamine; RuCl[(1R,2R)-p-TsNCH(Ph)-CH(Ph)NH2](η6-p-cymene) T=20°C; Noyori asymmetric transfer hydrogenation; P=30 Torr; 0.75 h;
参考文献
Tanis, Steven P.; Evans, Bruce R.; Nieman, James A.; Parker, Timothy T.; Taylor, Wendy D.; Heasley, Steven E.; Herrinton, Paul M.; Perrault, William R.; Hohler, Richard A.; Dolak, Lester A.; Hester, Matthew R.; Seest, Eric P.
Tetrahedron Asymmetry, 2006 , vol. 17, # 14 p. 2154 - 2182
反应条件
sodium hydrogencarbonate in tetrahydrofuran; methanol; dichloromethane; water
反应条件
formic acid; triethylamine; chloro[(1R,2R)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine] (pentamethylcyclopentadienyl) rhodium in ethyl acetate T=25°C; 2 h; Title compound not separated from byproducts.;
参考文献
Tetrahedron, , vol. 60, # 34 p. 7411 - 7417
反应条件
1: hydrogenchloride; N-chloro-succinimide / diethyl ether; acetic acid 2: sodium borohydride / methanol View Scheme
参考文献
US6469031 B1, ;
US 6469031 B1
US6051586 A1, ;
US 6051586 A
反应条件
Candida antarctica SP435-L lipase in hexane T=37°C; 144 h; Product distribution; Further Variations:Reagents;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 14, # 4 p. 1207 - 1214
