sodium hydroxide in tetrahydrofuran

sodium hydroxide in 2-methyl tetrahydrofuran 0.5 h;

sodium hydroxide in tetrahydrofuran

1: 79 percent / t-BuOMe 2: 73 percent / bromobarbituric acid / tetrahydrofuran / Heating 3: 84 percent / (-)-B-chlorodiisopinocampheylborane / tetrahydrofuran / -25 °C 4: 93 percent / 5N aq. NaOH / tetrahydrofuran View Scheme

1: 73 percent / bromobarbituric acid / tetrahydrofuran / Heating 2: 84 percent / (-)-B-chlorodiisopinocampheylborane / tetrahydrofuran / -25 °C 3: 93 percent / 5N aq. NaOH / tetrahydrofuran View Scheme

1.1: n-butyllithium / tetrahydrofuran; tert-butyl methyl ether / 1 h / -75 - -65 °C 1.2: 2 h / -65 - -5 °C 1.3: 0.17 h / -5 - 2 °C 2.1: [Ru2(p-PriC6H4Me)2(μ-Cl)Cl]2; formic acid; triethylamine; N,N-dimethyl-formamide; N-[(1S,2S)-2-amino-1,2-diphenylethyl]-p-tolylsulphonamide / tert-butyl methyl ether / 3.58 h / 20 °C 2.2: 0.83 h 3.1: sodium hydroxide / 2-methyl tetrahydrofuran / 0.5 h View Scheme