(2S,4R)-N-Boc-4-羟基-3,3-二甲基吡咯烷-2-甲酸合成路线 （共 4 条）
反应条件
sodium cyanoborohydride; acetic acid in dichloromethane T=0 - 20°C;
参考文献
INTERMUNE, INC.; BUCKMAN, Brad; NICHOLAS, John, B.; SEREBRYANY, Vladimir; SEIWERT, Scott, D.
Patent: WO2012/40242 A1, 2012 ;
Location in patent: Page/Page column 183 ;
WO 2012/040242 A1
反应条件
hydrogen; palladium on activated charcoal in tetrahydrofuran P=3800 Torr; 48 h;
参考文献
Sharma, Raman; Lubell, William D.
Journal of Organic Chemistry, 1996 , vol. 61, # 1 p. 202 - 209
反应条件
1: 32 percent / LiAlH4 / tetrahydrofuran / 0.5 h / -78 °C 2: 93 percent / H2 / Pd/C / tetrahydrofuran / 48 h / 3800 Torr View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 1 p. 202 - 209
反应条件
1.1: trifluoroacetic acid / dichloromethane / 4 h / 20 - 35 °C 1.2: 1 h / 20 °C 1.3: pH 2 - 3 2.1: sodium cyanoborohydride; acetic acid / dichloromethane / 0 - 20 °C View Scheme
参考文献
WO2012/40242 A1, ;
WO 2012/040242 A1
